Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function

Vertebrate Hedgehog (HH) signaling is controlled by several ligand-binding antagonists including Patched-1 (PTCH1), PTCH2, and HH-interacting protein 1 (HHIP1), whose collective action is essential for proper HH pathway activity. However, the molecular mechanisms used by these inhibitors remain poor...

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Detalles Bibliográficos
Autores principales: Holtz, Alexander M., Griffiths, Samuel C., Davis, Samantha J., Bishop, Benjamin, Siebold, Christian, Allen, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460154/
https://www.ncbi.nlm.nih.gov/pubmed/26056142
http://dx.doi.org/10.1083/jcb.201411024

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