Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside...

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Detalles Bibliográficos
Autores principales: Danciu, Corina, Soica, Codruta, Dehelean, Cristina, Zupko, Istvan, Csanyi, Erzsebet, Pinzaru, Iulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460206/
https://www.ncbi.nlm.nih.gov/pubmed/26161301
http://dx.doi.org/10.1155/2015/262930
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author Danciu, Corina
Soica, Codruta
Dehelean, Cristina
Zupko, Istvan
Csanyi, Erzsebet
Pinzaru, Iulia
author_facet Danciu, Corina
Soica, Codruta
Dehelean, Cristina
Zupko, Istvan
Csanyi, Erzsebet
Pinzaru, Iulia
author_sort Danciu, Corina
collection PubMed
description The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.
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spelling pubmed-44602062015-07-09 Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation Danciu, Corina Soica, Codruta Dehelean, Cristina Zupko, Istvan Csanyi, Erzsebet Pinzaru, Iulia Anal Cell Pathol (Amst) Research Article The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment. Hindawi Publishing Corporation 2015 2015-05-26 /pmc/articles/PMC4460206/ /pubmed/26161301 http://dx.doi.org/10.1155/2015/262930 Text en Copyright © 2015 Corina Danciu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Danciu, Corina
Soica, Codruta
Dehelean, Cristina
Zupko, Istvan
Csanyi, Erzsebet
Pinzaru, Iulia
Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_full Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_fullStr Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_full_unstemmed Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_short Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_sort preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460206/
https://www.ncbi.nlm.nih.gov/pubmed/26161301
http://dx.doi.org/10.1155/2015/262930
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