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Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia

The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk mar...

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Autores principales: Serrano-Fernandez, Pablo, Dymerska, Dagmara, Kurzawski, Grzegorz, Derkacz, Róża, Sobieszczańska, Tatiana, Banaszkiewicz, Zbigniew, Roomere, Hanno, Oitmaa, Eneli, Metspalu, Andres, Janavičius, Ramūnas, Elsakov, Pavel, Razumas, Mindaugas, Petrulis, Kestutis, Irmejs, Arvīds, Miklaševičs, Edvīns, Scott, Rodney J., Lubiński, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460249/
https://www.ncbi.nlm.nih.gov/pubmed/26101521
http://dx.doi.org/10.1155/2015/204089
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author Serrano-Fernandez, Pablo
Dymerska, Dagmara
Kurzawski, Grzegorz
Derkacz, Róża
Sobieszczańska, Tatiana
Banaszkiewicz, Zbigniew
Roomere, Hanno
Oitmaa, Eneli
Metspalu, Andres
Janavičius, Ramūnas
Elsakov, Pavel
Razumas, Mindaugas
Petrulis, Kestutis
Irmejs, Arvīds
Miklaševičs, Edvīns
Scott, Rodney J.
Lubiński, Jan
author_facet Serrano-Fernandez, Pablo
Dymerska, Dagmara
Kurzawski, Grzegorz
Derkacz, Róża
Sobieszczańska, Tatiana
Banaszkiewicz, Zbigniew
Roomere, Hanno
Oitmaa, Eneli
Metspalu, Andres
Janavičius, Ramūnas
Elsakov, Pavel
Razumas, Mindaugas
Petrulis, Kestutis
Irmejs, Arvīds
Miklaševičs, Edvīns
Scott, Rodney J.
Lubiński, Jan
author_sort Serrano-Fernandez, Pablo
collection PubMed
description The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls), Latvia (81 cases and controls), Lithuania (123 cases and controls), and Poland (795 cases and controls). Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample). Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.
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spelling pubmed-44602492015-06-22 Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia Serrano-Fernandez, Pablo Dymerska, Dagmara Kurzawski, Grzegorz Derkacz, Róża Sobieszczańska, Tatiana Banaszkiewicz, Zbigniew Roomere, Hanno Oitmaa, Eneli Metspalu, Andres Janavičius, Ramūnas Elsakov, Pavel Razumas, Mindaugas Petrulis, Kestutis Irmejs, Arvīds Miklaševičs, Edvīns Scott, Rodney J. Lubiński, Jan Gastroenterol Res Pract Research Article The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls), Latvia (81 cases and controls), Lithuania (123 cases and controls), and Poland (795 cases and controls). Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample). Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers. Hindawi Publishing Corporation 2015 2015-05-26 /pmc/articles/PMC4460249/ /pubmed/26101521 http://dx.doi.org/10.1155/2015/204089 Text en Copyright © 2015 Pablo Serrano-Fernandez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Serrano-Fernandez, Pablo
Dymerska, Dagmara
Kurzawski, Grzegorz
Derkacz, Róża
Sobieszczańska, Tatiana
Banaszkiewicz, Zbigniew
Roomere, Hanno
Oitmaa, Eneli
Metspalu, Andres
Janavičius, Ramūnas
Elsakov, Pavel
Razumas, Mindaugas
Petrulis, Kestutis
Irmejs, Arvīds
Miklaševičs, Edvīns
Scott, Rodney J.
Lubiński, Jan
Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title_full Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title_fullStr Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title_full_unstemmed Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title_short Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
title_sort cumulative small effect genetic markers and the risk of colorectal cancer in poland, estonia, lithuania, and latvia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460249/
https://www.ncbi.nlm.nih.gov/pubmed/26101521
http://dx.doi.org/10.1155/2015/204089
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