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Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels

Cyclic nucleotide gated (CNG) channels are a critical component of the visual transduction cascade in the vertebrate retina. Mutations in the genes encoding these channels have been associated with a spectrum of inherited retinal disorders. To gain insight into their pathophysiological mechanisms, w...

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Detalles Bibliográficos
Autores principales:	Meighan, Peter C., Peng, Changhong, Varnum, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460308/ https://www.ncbi.nlm.nih.gov/pubmed/26106334 http://dx.doi.org/10.3389/fphys.2015.00177

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