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Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems

The bacterial proteins of the Dsb family—important components of the post-translational protein modification system—catalyze the formation of disulfide bridges, a process that is crucial for protein structure stabilization and activity. Dsb systems play an essential role in the assembly of many viru...

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Autores principales: Bocian-Ostrzycka, Katarzyna M., Grzeszczuk, Magdalena J., Dziewit, Lukasz, Jagusztyn-Krynicka, Elżbieta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460558/
https://www.ncbi.nlm.nih.gov/pubmed/26106374
http://dx.doi.org/10.3389/fmicb.2015.00570
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author Bocian-Ostrzycka, Katarzyna M.
Grzeszczuk, Magdalena J.
Dziewit, Lukasz
Jagusztyn-Krynicka, Elżbieta K.
author_facet Bocian-Ostrzycka, Katarzyna M.
Grzeszczuk, Magdalena J.
Dziewit, Lukasz
Jagusztyn-Krynicka, Elżbieta K.
author_sort Bocian-Ostrzycka, Katarzyna M.
collection PubMed
description The bacterial proteins of the Dsb family—important components of the post-translational protein modification system—catalyze the formation of disulfide bridges, a process that is crucial for protein structure stabilization and activity. Dsb systems play an essential role in the assembly of many virulence factors. Recent rapid advances in global analysis of bacteria have thrown light on the enormous diversity among bacterial Dsb systems. While the Escherichia coli disulfide bond-forming system is quite well understood, the mechanisms of action of Dsb systems in other bacteria, including members of class Epsilonproteobacteria that contain pathogenic and non-pathogenic bacteria colonizing extremely diverse ecological niches, are poorly characterized. Here we present a review of current knowledge on Epsilonproteobacteria Dsb systems. We have focused on the Dsb systems of Campylobacter spp. and Helicobacter spp. because our knowledge about Dsb proteins of Wolinella and Arcobacter spp. is still scarce and comes mainly from bioinformatic studies. Helicobacter pylori is a common human pathogen that colonizes the gastric epithelium of humans with severe consequences. Campylobacter spp. is a leading cause of zoonotic enteric bacterial infections in most developed and developing nations. We focus on various aspects of the diversity of the Dsb systems and their influence on pathogenicity, particularly because Dsb proteins are considered as potential targets for a new class of anti-virulence drugs to treat human infections by Campylobacter or Helicobacter spp.
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spelling pubmed-44605582015-06-23 Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems Bocian-Ostrzycka, Katarzyna M. Grzeszczuk, Magdalena J. Dziewit, Lukasz Jagusztyn-Krynicka, Elżbieta K. Front Microbiol Microbiology The bacterial proteins of the Dsb family—important components of the post-translational protein modification system—catalyze the formation of disulfide bridges, a process that is crucial for protein structure stabilization and activity. Dsb systems play an essential role in the assembly of many virulence factors. Recent rapid advances in global analysis of bacteria have thrown light on the enormous diversity among bacterial Dsb systems. While the Escherichia coli disulfide bond-forming system is quite well understood, the mechanisms of action of Dsb systems in other bacteria, including members of class Epsilonproteobacteria that contain pathogenic and non-pathogenic bacteria colonizing extremely diverse ecological niches, are poorly characterized. Here we present a review of current knowledge on Epsilonproteobacteria Dsb systems. We have focused on the Dsb systems of Campylobacter spp. and Helicobacter spp. because our knowledge about Dsb proteins of Wolinella and Arcobacter spp. is still scarce and comes mainly from bioinformatic studies. Helicobacter pylori is a common human pathogen that colonizes the gastric epithelium of humans with severe consequences. Campylobacter spp. is a leading cause of zoonotic enteric bacterial infections in most developed and developing nations. We focus on various aspects of the diversity of the Dsb systems and their influence on pathogenicity, particularly because Dsb proteins are considered as potential targets for a new class of anti-virulence drugs to treat human infections by Campylobacter or Helicobacter spp. Frontiers Media S.A. 2015-06-09 /pmc/articles/PMC4460558/ /pubmed/26106374 http://dx.doi.org/10.3389/fmicb.2015.00570 Text en Copyright © 2015 Bocian-Ostrzycka, Grzeszczuk, Dziewit and Jagusztyn-Krynicka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bocian-Ostrzycka, Katarzyna M.
Grzeszczuk, Magdalena J.
Dziewit, Lukasz
Jagusztyn-Krynicka, Elżbieta K.
Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title_full Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title_fullStr Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title_full_unstemmed Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title_short Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
title_sort diversity of the epsilonproteobacteria dsb (disulfide bond) systems
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460558/
https://www.ncbi.nlm.nih.gov/pubmed/26106374
http://dx.doi.org/10.3389/fmicb.2015.00570
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