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Valsartan blocks thrombospondin/transforming growth factor/Smads to inhibit aortic remodeling in diabetic rats

BACKGROUND: Angiotensin II (Ang II) and transforming growth factor β (TGFβ) are closely involved in the pathogenesis of diabetic complications. We aimed to determine whether an aberrant thrombospondin 1 (TSP1)–mediated TGFβ1/Smads signaling pathway specifically affects vascular fibrosis in diabetic...

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Detalles Bibliográficos
Autores principales:	Sun, Hui, Zhao, Yong, Bi, Xiuping, Li, Shaohua, Su, Guohai, Miao, Ya, Ma, Xiao, Zhang, Yun, Zhang, Wei, Zhong, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460645/ https://www.ncbi.nlm.nih.gov/pubmed/25884585 http://dx.doi.org/10.1186/s13000-015-0246-8

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