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Mixed response and time-to-event endpoints for multistage single-arm phase II design
BACKGROUND: The objective of phase II cancer clinical trials is to determine if a treatment has sufficient activity to warrant further study. The efficiency of a conventional phase II trial design has been the object of considerable debate, particularly when the study regimen is characteristically c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460691/ https://www.ncbi.nlm.nih.gov/pubmed/26037094 http://dx.doi.org/10.1186/s13063-015-0743-9 |