The critical role of membralin in postnatal motor neuron survival and disease

Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lower motor neurons, including those innervating the limbs, int...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Bo, Qu, Mingliang, Wang, Rengang, Chatterton, Jon E, Liu, Xiao-Bo, Zhu, Bing, Narisawa, Sonoko, Millan, Jose Luis, Nakanishi, Nobuki, Swoboda, Kathryn, Lipton, Stuart A, Zhang, Dongxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460860/
https://www.ncbi.nlm.nih.gov/pubmed/25977983
http://dx.doi.org/10.7554/eLife.06500

Ejemplares similares

Ejemplares similares