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WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients

DNA-damaging agents are commonly used for first-line chemotherapy of advanced non-small cell lung cancer (NSCLC). As a G2/M checkpoint kinase, Wee1 can phosphorylate CDC2-tyr15 and induce G2/M cell cycle arrest in response to DNA damage. The correlation of WEE1 polymorphisms to the efficacy of chemo...

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Detalles Bibliográficos
Autores principales:	Liu, Di, Wu, Chunyan, Jiao, Yuli, Hou, Likun, Lu, Daru, Zheng, Hui, Chen, Chang, Qian, Ji, Fei, Ke, Su, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460872/ https://www.ncbi.nlm.nih.gov/pubmed/26057002 http://dx.doi.org/10.1038/srep11114

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