Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity

The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to the S46 family of serine peptidases and preferentially cleaves substrates with Asp/Glu at the P1 position. The molecular mechanism underlying the substrate specificity of PgDPP11, however, is unknown. Here, we report the...

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Detalles Bibliográficos
Autores principales: Sakamoto, Yasumitsu, Suzuki, Yoshiyuki, Iizuka, Ippei, Tateoka, Chika, Roppongi, Saori, Fujimoto, Mayu, Inaka, Koji, Tanaka, Hiroaki, Yamada, Mitsugu, Ohta, Kazunori, Gouda, Hiroaki, Nonaka, Takamasa, Ogasawara, Wataru, Tanaka, Nobutada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460893/
https://www.ncbi.nlm.nih.gov/pubmed/26057589
http://dx.doi.org/10.1038/srep11151

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