Cargando…

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

Microglia have been shown to contribute to the clearance of brain amyloid β peptides (Aβ), the major component of amyloid plaques, in Alzheimer’s disease (AD). However, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (NFTs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Wenjie, Liu, Wencheng, Hu, Xiaoyan, Hanna, Mary, Caravaca, April, Paul, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460904/ https://www.ncbi.nlm.nih.gov/pubmed/26057852 http://dx.doi.org/10.1038/srep11161

Ejemplares similares

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)
por: Gibbons, Garrett S., et al.
Publicado: (2019)

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
por: Gibbons, Garrett S., et al.
Publicado: (2020)

TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration
por: Fassler, Michael, et al.
Publicado: (2023)

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
por: Romero-Molina, Carmen, et al.
Publicado: (2018)

Microglial microRNAs mediate sex-specific responses to tau pathology
por: Kodama, Lay, et al.
Publicado: (2019)

Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model
por: Goñi, Fernando, et al.
Publicado: (2018)

Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism
por: Cooper, Joanna M., et al.
Publicado: (2021)

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
por: Agadjanyan, Michael G., et al.
Publicado: (2017)

Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model
por: Shamir, Dov B., et al.
Publicado: (2020)

Anti-tau antibody reduces insoluble tau and decreases brain atrophy
por: Yanamandra, Kiran, et al.
Publicado: (2015)

Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer’s Mouse Model With Tau Pathology
por: Boutajangout, Allal, et al.
Publicado: (2021)

Tau Protein: Function and Pathology
por: Rosenmann, Hanna, et al.
Publicado: (2012)

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8
por: Malia, Thomas J., et al.
Publicado: (2016)

Neurons Expressing Pathological Tau Protein Trigger Dramatic Changes in Microglial Morphology and Dynamics
por: Hassan-Abdi, Rahma, et al.
Publicado: (2019)

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
por: Congdon, Erin E., et al.
Publicado: (2016)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Pathological conformations involving the amino terminus of tau occur early in Alzheimer’s disease and are differentially detected by monoclonal antibodies
por: Combs, Benjamin, et al.
Publicado: (2016)

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
por: Španić, Ena, et al.
Publicado: (2019)

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
por: Vitale, Francesca, et al.
Publicado: (2018)

Biomarkers for tau pathology
por: Schöll, Michael, et al.
Publicado: (2019)

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein
por: Chukwu, Jessica E., et al.
Publicado: (2018)

Neuronal activity enhances tau propagation and tau pathology in vivo
por: Wu, Jessica W., et al.
Publicado: (2016)

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology
por: Yamada, Kaoru
Publicado: (2017)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
por: Mattsson‐Carlgren, Niklas, et al.
Publicado: (2021)

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
por: Guedes, Joana R., et al.
Publicado: (2018)

Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum
por: Chen, Yi-He, et al.
Publicado: (2022)

Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
por: Pereira, Joana B., et al.
Publicado: (2022)

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2016)

Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits
por: Jin, Youngnam N., et al.
Publicado: (2012)

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
por: Courade, Jean-Philippe, et al.
Publicado: (2018)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
por: Zhao, Shuai, et al.
Publicado: (2022)

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration
por: Drieu, Antoine, et al.
Publicado: (2023)

Insulin dysfunction and Tau pathology
por: El Khoury, Noura B., et al.
Publicado: (2014)

Tau Pathology in Parkinson's Disease
por: Zhang, Xue, et al.
Publicado: (2018)

Imaging tau pathology in Parkinsonisms
por: Coakeley, Sarah, et al.
Publicado: (2017)

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
por: Alquezar, Carolina, et al.
Publicado: (2021)

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
por: Sankaranarayanan, Sethu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u1ggi918ob6hpnto65022fc37p