Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9

Genome editing, which introduces mutations in genes of interest using artificial DNA nucleases such as the ZFN, TALEN, and CRISPR/Cas9 systems in living cells, is a useful tool for generating mutant animals. Although CRISPR/Cas9 provides advantages over the two other systems, such as an easier vecto...

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Detalles Bibliográficos
Autores principales: Hara, Satoshi, Tamano, Moe, Yamashita, Satoshi, Kato, Tomoko, Saito, Takeshi, Sakuma, Tetsushi, Yamamoto, Takashi, Inui, Masafumi, Takada, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460908/
https://www.ncbi.nlm.nih.gov/pubmed/26057433
http://dx.doi.org/10.1038/srep11221

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