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Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

BACKGROUND: Malignant melanoma has an increasing incidence rate and the metastatic disease is notoriously resistant to standard chemotherapy. Loss of cell cycle checkpoints is frequently found in many cancer types and makes the cells reliant on compensatory mechanisms to control progression. This fe...

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Detalles Bibliográficos
Autores principales:	Magnussen, Gry Irene, Emilsen, Elisabeth, Giller Fleten, Karianne, Engesæter, Birgit, Nähse-Kumpf, Viola, Fjær, Roar, Slipicevic, Ana, Flørenes, Vivi Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460948/ https://www.ncbi.nlm.nih.gov/pubmed/26054341 http://dx.doi.org/10.1186/s12885-015-1474-8

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