Cargando…

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

RATIONALE: Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no curative therapies available. Recent findings suggest a key role of NO and sGC-cGMP signaling for the pathogenesis of the disease. Previous data suggest a downregulation/inactivation of the cGMP producing solubl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Bednorz, Mariola, Ghofrani, Hossein Ardeschir, Schermuly, Ralph Theo, Seeger, Werner, Grimminger, Friedrich, Weissmann, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461257/ https://www.ncbi.nlm.nih.gov/pubmed/26058042 http://dx.doi.org/10.1371/journal.pone.0129327

Ejemplares similares

Reply to Bogaard et al.: Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension
por: Kojonazarov, Baktybek, et al.
Publicado: (2019)

Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
por: Schermuly, Ralph Theo, et al.
Publicado: (2005)

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling
por: Tian, Xia, et al.
Publicado: (2011)

Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice
por: Hadzic, Stefan, et al.
Publicado: (2023)

Correction to: Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
por: Udalov, Sergey, et al.
Publicado: (2022)

Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension
por: Veeroju, Swathi, et al.
Publicado: (2021)

Effects of riociguat in severe experimental pulmonary hypertension
por: Kojonazarov, Baktybek, et al.
Publicado: (2011)

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
por: Lang, Michaela, et al.
Publicado: (2011)

Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
por: Pullamsetti, Soni, et al.
Publicado: (2005)

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
por: Udalov, Sergey, et al.
Publicado: (2010)

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis
por: Nikolova, Sevdalina, et al.
Publicado: (2010)

Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension
por: Sklepkiewicz, Piotr, et al.
Publicado: (2011)

Correction to: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis
por: Nikolova, Sevdalina, et al.
Publicado: (2022)

Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice
por: Janssen, Wiebke, et al.
Publicado: (2011)

Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice
por: Janssen, Wiebke, et al.
Publicado: (2011)

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats
por: Lang, Michaela, et al.
Publicado: (2012)

IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension
por: Biswas, Siladitta, et al.
Publicado: (2020)

Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema
por: Reimann, Sebastian, et al.
Publicado: (2015)

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
por: Fuchs, Beate, et al.
Publicado: (2011)

Genetic Deficiency and Pharmacological Stabilization of Mast Cells Ameliorate Pressure Overload-Induced Maladaptive Right Ventricular Remodeling in Mice
por: Sydykov, Akylbek, et al.
Publicado: (2020)

Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle
por: Luitel, Himal, et al.
Publicado: (2017)

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
por: Egemnazarov, Bakytbek, et al.
Publicado: (2009)

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β
por: Dahal, Bhola K., et al.
Publicado: (2011)

Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations
por: Roxlau, Elsa T., et al.
Publicado: (2023)

Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction
por: Ketabchi, Farzaneh, et al.
Publicado: (2012)

Smoking: Is it a risk factor for pulmonary vascular diseases?
por: Weissmann, Norbert, et al.
Publicado: (2012)

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
por: Egemnazarov, Bakytbek, et al.
Publicado: (2010)

Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury
por: Dumitrascu, Rio, et al.
Publicado: (2008)

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
por: Weiss, Astrid, et al.
Publicado: (2019)

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
por: Heidler, Juliana, et al.
Publicado: (2013)

Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
por: Schermuly, Ralph T, et al.
Publicado: (2007)

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding
por: Rai, Nabham, et al.
Publicado: (2018)

Response to: Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”
por: Rai, Nabham, et al.
Publicado: (2018)

iNOS Deletion in Alveolar Epithelium Cannot Reverse the Elastase-Induced Emphysema in Mice
por: Gredic, Marija, et al.
Publicado: (2022)

Modulating cGMP to Treat Lung Diseases
por: Ghofrani, Hossein-Ardeschir, et al.
Publicado: (2009)

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders
por: Sydykov, Akylbek, et al.
Publicado: (2021)

A novel noninvasive method for estimating right ventricular systolic pressure in rodents with pulmonary artery banding
por: Kojonazarov, Baktybek, et al.
Publicado: (2023)

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy
por: Weissmann, Norbert, et al.
Publicado: (2005)

Retraction: Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis
por: Boehm, Mario, et al.
Publicado: (2022)

Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
por: Dahal, Bhola K, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_v74eh4ot0dvi8od4ojv0tmgo56