Cargando…

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in colorectal cancer. Therefore, here we explored a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenjing, Shi, Xinpeng, Peng, Ying, Wu, Meiyan, Zhang, Pei, Xie, Ruyi, Wu, Yao, Yan, Qingqing, Liu, Side, Wang, Jide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461314/ https://www.ncbi.nlm.nih.gov/pubmed/26057751 http://dx.doi.org/10.1371/journal.pone.0129603

Ejemplares similares

Oncogene FOXK1 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition
por: Wu, Yao, et al.
Publicado: (2016)

FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition
por: Dong, Tianxiu, et al.
Publicado: (2016)

HOXD9 promote epithelial‐mesenchymal transition and metastasis in colorectal carcinoma
por: Liu, Mengwei, et al.
Publicado: (2020)

Overexpression of Srcin1 contributes to the growth and metastasis of colorectal cancer
por: Zhang, Mengnan, et al.
Publicado: (2017)

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2
por: Yan, Qingqing, et al.
Publicado: (2015)

Ovol2 induces mesenchymal–epithelial transition via targeting ZEB1 in osteosarcoma
por: Liu, Jijun, et al.
Publicado: (2018)

Overexpression of ZEB2‐AS1 promotes epithelial‐to‐mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma
por: Diao, Pengfei, et al.
Publicado: (2019)

PLAGL2 promotes epithelial–mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1
por: Wu, Liang, et al.
Publicado: (2019)

miR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma
por: GUO, FEI, et al.
Publicado: (2014)

Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells
por: Peng, Ying, et al.
Publicado: (2016)

HOXD9 promotes epithelial–mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
por: Lv, Xiupeng, et al.
Publicado: (2015)

PARK2 negatively regulates the metastasis and epithelial-mesenchymal transition of glioblastoma cells via ZEB1
por: Wang, Haiyang, et al.
Publicado: (2017)

Effect of AKT inhibition on epithelial-mesenchymal transition and ZEB1-potentiated radiotherapy in nasopharyngeal carcinoma
por: CHEN, WEIGUO, et al.
Publicado: (2013)

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
por: Kim, Taewan, et al.
Publicado: (2011)

The role of epithelial–mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel‐resistant prostate cancer
por: Hanrahan, Karen, et al.
Publicado: (2017)

Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2
por: Zhang, Guoxin, et al.
Publicado: (2019)

Polydatin inhibits ZEB1‐invoked epithelial‐mesenchymal transition in fructose‐induced liver fibrosis
por: Zhao, Xiaojuan, et al.
Publicado: (2020)

CPEB4 promotes growth and metastasis of gastric cancer cells via ZEB1-mediated epithelial– mesenchymal transition
por: Cao, Gan, et al.
Publicado: (2018)

Human antigen R enhances the epithelial-mesenchymal transition via regulation of ZEB-1 in the human airway epithelium
por: Sun, Jian, et al.
Publicado: (2018)

miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2
por: Li, Taiyuan, et al.
Publicado: (2021)

MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2
por: Kong, Xiangyi, et al.
Publicado: (2020)

RAE1 mediated ZEB1 expression promotes epithelial–mesenchymal transition in breast cancer
por: Oh, Ji Hoon, et al.
Publicado: (2019)

LINC01296/miR-141-3p/ZEB1-ZEB2 axis promotes tumor metastasis via enhancing epithelial-mesenchymal transition process
por: Sun, Zhenqiang, et al.
Publicado: (2021)

The VIM-AS1/miR-655/ZEB1 axis modulates bladder cancer cell metastasis by regulating epithelial–mesenchymal transition
por: Xiong, Yaoyao, et al.
Publicado: (2021)

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
por: Tam, Shing Yau, et al.
Publicado: (2020)

TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model
por: Leshem, Orit, et al.
Publicado: (2011)

Helicobacter pylori Initiates a Mesenchymal Transition through ZEB1 in Gastric Epithelial Cells
por: Baud, Jessica, et al.
Publicado: (2013)

FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition
por: Abshire, C F, et al.
Publicado: (2016)

Long non-coding RNA ZEB1-AS1 promotes cell invasion and epithelial to mesenchymal transition through inducing ZEB1 expression in cervical cancer
por: Cheng, Rongjie, et al.
Publicado: (2018)

lncRNA ZEB1-AS1 promotes pulmonary fibrosis through ZEB1-mediated epithelial–mesenchymal transition by competitively binding miR-141-3p
por: Qian, Weibin, et al.
Publicado: (2019)

Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
por: Wan, Guoqing, et al.
Publicado: (2020)

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer
por: Qin, Yong, et al.
Publicado: (2015)

Prognostic Role of Epithelial-Mesenchymal Transition Markers “E-Cadherin, β-Catenin, ZEB1, ZEB2 and p63” in Bladder Carcinoma
por: Moussa, Rabab Ahmed, et al.
Publicado: (2019)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2018)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2021)

LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation
por: Zhang, Jingjing, et al.
Publicado: (2016)

HOTAIR Contributes to Stemness Acquisition of Cervical Cancer through Regulating miR-203 Interaction with ZEB1 on Epithelial-Mesenchymal Transition
por: Zhang, Wenying, et al.
Publicado: (2021)

miR-1271 inhibits growth, invasion and epithelial–mesenchymal transition by targeting ZEB1 in ovarian cancer cells
por: Jiao, Yanni, et al.
Publicado: (2019)

HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway
por: Yang, Shi-wei, et al.
Publicado: (2017)

Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1
por: Carriere, Patrick P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5ess39lseieehihcft0ns3nsd0