A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens

Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines. Using human complement Factor H (FH) transgenic mice, we previously showed that binding of FH...

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Detalles Bibliográficos
Autores principales: Konar, Monica, Rossi, Raffaella, Walter, Helen, Pajon, Rolando, Beernink, Peter T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461315/
https://www.ncbi.nlm.nih.gov/pubmed/26057742
http://dx.doi.org/10.1371/journal.pone.0128185

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