Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold

When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re-exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against TRAIL receptors also cause fractional killing, even at saturat...

Descripción completa

Detalles Bibliográficos
Autores principales: Roux, Jérémie, Hafner, Marc, Bandara, Samuel, Sims, Joshua J, Hudson, Hannah, Chai, Diana, Sorger, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461398/
https://www.ncbi.nlm.nih.gov/pubmed/25953765
http://dx.doi.org/10.15252/msb.20145584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461398/
https://www.ncbi.nlm.nih.gov/pubmed/25953765
http://dx.doi.org/10.15252/msb.20145584

Ejemplares similares