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Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold

When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re-exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against TRAIL receptors also cause fractional killing, even at saturat...

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Detalles Bibliográficos
Autores principales:	Roux, Jérémie, Hafner, Marc, Bandara, Samuel, Sims, Joshua J, Hudson, Hannah, Chai, Diana, Sorger, Peter K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461398/ https://www.ncbi.nlm.nih.gov/pubmed/25953765 http://dx.doi.org/10.15252/msb.20145584

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