Tuning noise in gene expression

The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic l...

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Detalles Bibliográficos
Autor principal: Tyagi, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461399/
https://www.ncbi.nlm.nih.gov/pubmed/25943344
http://dx.doi.org/10.15252/msb.20156210
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author Tyagi, Sanjay
author_facet Tyagi, Sanjay
author_sort Tyagi, Sanjay
collection PubMed
description The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment.
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spelling pubmed-44613992015-06-15 Tuning noise in gene expression Tyagi, Sanjay Mol Syst Biol News & Views The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment. BlackWell Publishing Ltd 2015-05-05 /pmc/articles/PMC4461399/ /pubmed/25943344 http://dx.doi.org/10.15252/msb.20156210 Text en © 2015 The Author. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Tyagi, Sanjay
Tuning noise in gene expression
title Tuning noise in gene expression
title_full Tuning noise in gene expression
title_fullStr Tuning noise in gene expression
title_full_unstemmed Tuning noise in gene expression
title_short Tuning noise in gene expression
title_sort tuning noise in gene expression
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461399/
https://www.ncbi.nlm.nih.gov/pubmed/25943344
http://dx.doi.org/10.15252/msb.20156210
work_keys_str_mv AT tyagisanjay tuningnoiseingeneexpression

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