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H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

The host tolerance mechanisms to avian influenza virus (H5N1) infection that limit tissue injury remain unknown. Emerging evidence indicates that cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Cl(−) channel, modulates airway inflammation. Janus tyrosine kinase (JAK) 3,...

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Detalles Bibliográficos
Autores principales:	Cao, Ke, Chen, Minhui, Jie, Xiang, Wang, Yansheng, Li, Qiasheng, Xu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	ScholarOne 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461576/ https://www.ncbi.nlm.nih.gov/pubmed/25587856 http://dx.doi.org/10.2119/molmed.2014.00189

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