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Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection

The Japanese Classification of Gastric Carcinoma histologically classifies endoscopically resected gastric cancer into differentiated and undifferentiated types according to the presence or absence of tubular structures on histology. The former includes papillary adenocarcinoma and tubular types, an...

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Autores principales: Han, Yang Hee, Park, Jong Kyu, Kwon, Jun Sung, Kim, Young Don, Jeong, Woo Jin, Lee, Sang Jin, Han, Koon Hee, Cheon, Gab Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastrointestinal Endoscopy 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461670/
https://www.ncbi.nlm.nih.gov/pubmed/26064826
http://dx.doi.org/10.5946/ce.2015.48.3.247
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author Han, Yang Hee
Park, Jong Kyu
Kwon, Jun Sung
Kim, Young Don
Jeong, Woo Jin
Lee, Sang Jin
Han, Koon Hee
Cheon, Gab Jin
author_facet Han, Yang Hee
Park, Jong Kyu
Kwon, Jun Sung
Kim, Young Don
Jeong, Woo Jin
Lee, Sang Jin
Han, Koon Hee
Cheon, Gab Jin
author_sort Han, Yang Hee
collection PubMed
description The Japanese Classification of Gastric Carcinoma histologically classifies endoscopically resected gastric cancer into differentiated and undifferentiated types according to the presence or absence of tubular structures on histology. The former includes papillary adenocarcinoma and tubular types, and the latter includes poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous adenocarcinoma. However, gastric cancer sometimes contains a mixture of differentiated and undifferentiated components, and the clinical outcomes of the histological mixture are unknown, especially following endoscopic resection of early gastric cancer (EGC). This case was within the guideline indications for endoscopic submucosal resection (ESD), although it contained a partly signet ring cell carcinoma component; it recurred after 19 months with multiple lymph node and liver metastases. This case shows that additional surgical resection after ESD should be performed for patients with any mixed signet ring cell component, even in mild or moderately differentiated EGC.
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spelling pubmed-44616702015-06-10 Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection Han, Yang Hee Park, Jong Kyu Kwon, Jun Sung Kim, Young Don Jeong, Woo Jin Lee, Sang Jin Han, Koon Hee Cheon, Gab Jin Clin Endosc Case Report The Japanese Classification of Gastric Carcinoma histologically classifies endoscopically resected gastric cancer into differentiated and undifferentiated types according to the presence or absence of tubular structures on histology. The former includes papillary adenocarcinoma and tubular types, and the latter includes poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous adenocarcinoma. However, gastric cancer sometimes contains a mixture of differentiated and undifferentiated components, and the clinical outcomes of the histological mixture are unknown, especially following endoscopic resection of early gastric cancer (EGC). This case was within the guideline indications for endoscopic submucosal resection (ESD), although it contained a partly signet ring cell carcinoma component; it recurred after 19 months with multiple lymph node and liver metastases. This case shows that additional surgical resection after ESD should be performed for patients with any mixed signet ring cell component, even in mild or moderately differentiated EGC. The Korean Society of Gastrointestinal Endoscopy 2015-05 2015-05-29 /pmc/articles/PMC4461670/ /pubmed/26064826 http://dx.doi.org/10.5946/ce.2015.48.3.247 Text en Copyright © 2015 Korean Society of Gastrointestinal Endoscopy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Han, Yang Hee
Park, Jong Kyu
Kwon, Jun Sung
Kim, Young Don
Jeong, Woo Jin
Lee, Sang Jin
Han, Koon Hee
Cheon, Gab Jin
Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title_full Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title_fullStr Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title_full_unstemmed Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title_short Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection
title_sort liver metastasis of early gastric cancer with mixed histology after endoscopic submucosal dissection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461670/
https://www.ncbi.nlm.nih.gov/pubmed/26064826
http://dx.doi.org/10.5946/ce.2015.48.3.247
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