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Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update
The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retrovir...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461820/ https://www.ncbi.nlm.nih.gov/pubmed/26113810 http://dx.doi.org/10.3389/fncel.2015.00212 |
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author | Atluri, Venkata Subba Rao Hidalgo, Melissa Samikkannu, Thangavel Kurapati, Kesava Rao Venkata Jayant, Rahul Dev Sagar, Vidya Nair, Madhavan P. N. |
author_facet | Atluri, Venkata Subba Rao Hidalgo, Melissa Samikkannu, Thangavel Kurapati, Kesava Rao Venkata Jayant, Rahul Dev Sagar, Vidya Nair, Madhavan P. N. |
author_sort | Atluri, Venkata Subba Rao |
collection | PubMed |
description | The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neurological diseases. Human Immunodeficiency Virus (HIV) infection in the Central Nervous System (CNS) is an early event even before the serodiagnosis for HIV positivity or the initiation of antiretroviral therapy (ART), resulting in neurological complications in many of the infected patients. Macrophages, microglia and astrocytes (in low levels) are the most productively/latently infected cell types within the CNS. In this brief review, we have discussed about the effect of HIV infection and viral proteins on the integrity and function of BBB, which may contribute to the progression of HIV associated neurocognitive disorders. |
format | Online Article Text |
id | pubmed-4461820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44618202015-06-25 Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update Atluri, Venkata Subba Rao Hidalgo, Melissa Samikkannu, Thangavel Kurapati, Kesava Rao Venkata Jayant, Rahul Dev Sagar, Vidya Nair, Madhavan P. N. Front Cell Neurosci Neuroscience The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neurological diseases. Human Immunodeficiency Virus (HIV) infection in the Central Nervous System (CNS) is an early event even before the serodiagnosis for HIV positivity or the initiation of antiretroviral therapy (ART), resulting in neurological complications in many of the infected patients. Macrophages, microglia and astrocytes (in low levels) are the most productively/latently infected cell types within the CNS. In this brief review, we have discussed about the effect of HIV infection and viral proteins on the integrity and function of BBB, which may contribute to the progression of HIV associated neurocognitive disorders. Frontiers Media S.A. 2015-06-10 /pmc/articles/PMC4461820/ /pubmed/26113810 http://dx.doi.org/10.3389/fncel.2015.00212 Text en Copyright © 2015 Atluri, Hidalgo, Samikkannu, Kurapati, Jayant, Sagar and Nair. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Atluri, Venkata Subba Rao Hidalgo, Melissa Samikkannu, Thangavel Kurapati, Kesava Rao Venkata Jayant, Rahul Dev Sagar, Vidya Nair, Madhavan P. N. Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title | Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title_full | Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title_fullStr | Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title_full_unstemmed | Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title_short | Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
title_sort | effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461820/ https://www.ncbi.nlm.nih.gov/pubmed/26113810 http://dx.doi.org/10.3389/fncel.2015.00212 |
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