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Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma
INTRODUCTION: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461844/ https://www.ncbi.nlm.nih.gov/pubmed/26082902 |
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author | Lotfi, Alireza Shahidi, Nikzad Bayazian, Gholamreza AbdollahiFakhim, Shahin Estakhri, Rasoul Esfahani, Ali Notash, Rezvan |
author_facet | Lotfi, Alireza Shahidi, Nikzad Bayazian, Gholamreza AbdollahiFakhim, Shahin Estakhri, Rasoul Esfahani, Ali Notash, Rezvan |
author_sort | Lotfi, Alireza |
collection | PubMed |
description | INTRODUCTION: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC. MATERIALS AND METHODS: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects’ age, gender, drinking and smoking history, cancer site, and disease severity. RESULTS: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P<0.001). Serum IL-6 level was independent of the patients’ age, gender, smoking and drinking history as well as cancer stage. CONCLUSION: IL-6 is a valuable biomarker in the diagnosis of oral tongue SCC. Its high sensitivity makes prediction of this condition possible, while this biomarker can also be used to screen high-risk patients. |
format | Online Article Text |
id | pubmed-4461844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44618442015-06-16 Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma Lotfi, Alireza Shahidi, Nikzad Bayazian, Gholamreza AbdollahiFakhim, Shahin Estakhri, Rasoul Esfahani, Ali Notash, Rezvan Iran J Otorhinolaryngol Original Article INTRODUCTION: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC. MATERIALS AND METHODS: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects’ age, gender, drinking and smoking history, cancer site, and disease severity. RESULTS: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P<0.001). Serum IL-6 level was independent of the patients’ age, gender, smoking and drinking history as well as cancer stage. CONCLUSION: IL-6 is a valuable biomarker in the diagnosis of oral tongue SCC. Its high sensitivity makes prediction of this condition possible, while this biomarker can also be used to screen high-risk patients. Mashhad University of Medical Sciences 2015-05 /pmc/articles/PMC4461844/ /pubmed/26082902 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lotfi, Alireza Shahidi, Nikzad Bayazian, Gholamreza AbdollahiFakhim, Shahin Estakhri, Rasoul Esfahani, Ali Notash, Rezvan Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title | Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title_full | Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title_fullStr | Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title_full_unstemmed | Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title_short | Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma |
title_sort | serum level of interleukin-6 in patients with oral tongue squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461844/ https://www.ncbi.nlm.nih.gov/pubmed/26082902 |
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