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Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461910/ https://www.ncbi.nlm.nih.gov/pubmed/25880202 http://dx.doi.org/10.1186/s12872-015-0018-0 |
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author | Sun, Hui Guan, Yuqing Wang, Lei Zhao, Yong Lv, Hong Bi, Xiuping Wang, Huating Zhang, Xuejing Liu, Li Wei, Min Song, Hui Su, Guohai |
author_facet | Sun, Hui Guan, Yuqing Wang, Lei Zhao, Yong Lv, Hong Bi, Xiuping Wang, Huating Zhang, Xuejing Liu, Li Wei, Min Song, Hui Su, Guohai |
author_sort | Sun, Hui |
collection | PubMed |
description | BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mortality in patients with diabetes is uncertain. METHODS: We performed a meta-analysis of results from randomized controlled trials (RCTs) of the long-term outcome of cardiac resynchronization therapy for heart failure in diabetic and non-diabetic patients. Literature search of MEDLINE via Pubmed for reports of randomized controlled trials of Cardiac resynchronization for chronic symptomatic left-ventricular dysfunction in patients with and without diabetes mellitus, with death as the outcome. Relevant data were analyzed by use of a random-effects model. Reports published from 1994 to 2011 that described RCTs of CRT for treating chronic symptomatic left ventricular dysfunction in patients with and without diabetes, with all-cause mortality as an outcome. RESULTS: A total of 5 randomized controlled trials met the inclusion criteria, for 2,923 patients. The quality of studies was good to moderate. Cardiac resynchronization significantly reduced the mortality for heart failure patients with or without diabetes mellitus. Mortality was 24.3% for diabetic patients with heart failure and 20.4 % for non-diabetics (odds ratio 1.28, 95% confidence interval 1.06–1.55; P = 0.010). CONCLUSIONS: Cardiac resynchronization therapy (CRT) may reduce mortality from progressive heart failure in patients with or without diabetes mellitus, but mortality may be higher for patients with than without diabetes after CRT for heart failure. |
format | Online Article Text |
id | pubmed-4461910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44619102015-06-11 Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis Sun, Hui Guan, Yuqing Wang, Lei Zhao, Yong Lv, Hong Bi, Xiuping Wang, Huating Zhang, Xuejing Liu, Li Wei, Min Song, Hui Su, Guohai BMC Cardiovasc Disord Research Article BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mortality in patients with diabetes is uncertain. METHODS: We performed a meta-analysis of results from randomized controlled trials (RCTs) of the long-term outcome of cardiac resynchronization therapy for heart failure in diabetic and non-diabetic patients. Literature search of MEDLINE via Pubmed for reports of randomized controlled trials of Cardiac resynchronization for chronic symptomatic left-ventricular dysfunction in patients with and without diabetes mellitus, with death as the outcome. Relevant data were analyzed by use of a random-effects model. Reports published from 1994 to 2011 that described RCTs of CRT for treating chronic symptomatic left ventricular dysfunction in patients with and without diabetes, with all-cause mortality as an outcome. RESULTS: A total of 5 randomized controlled trials met the inclusion criteria, for 2,923 patients. The quality of studies was good to moderate. Cardiac resynchronization significantly reduced the mortality for heart failure patients with or without diabetes mellitus. Mortality was 24.3% for diabetic patients with heart failure and 20.4 % for non-diabetics (odds ratio 1.28, 95% confidence interval 1.06–1.55; P = 0.010). CONCLUSIONS: Cardiac resynchronization therapy (CRT) may reduce mortality from progressive heart failure in patients with or without diabetes mellitus, but mortality may be higher for patients with than without diabetes after CRT for heart failure. BioMed Central 2015-03-21 /pmc/articles/PMC4461910/ /pubmed/25880202 http://dx.doi.org/10.1186/s12872-015-0018-0 Text en © Sun et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sun, Hui Guan, Yuqing Wang, Lei Zhao, Yong Lv, Hong Bi, Xiuping Wang, Huating Zhang, Xuejing Liu, Li Wei, Min Song, Hui Su, Guohai Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title | Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title_full | Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title_fullStr | Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title_full_unstemmed | Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title_short | Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
title_sort | influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461910/ https://www.ncbi.nlm.nih.gov/pubmed/25880202 http://dx.doi.org/10.1186/s12872-015-0018-0 |
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