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Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis

BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mo...

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Autores principales: Sun, Hui, Guan, Yuqing, Wang, Lei, Zhao, Yong, Lv, Hong, Bi, Xiuping, Wang, Huating, Zhang, Xuejing, Liu, Li, Wei, Min, Song, Hui, Su, Guohai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461910/
https://www.ncbi.nlm.nih.gov/pubmed/25880202
http://dx.doi.org/10.1186/s12872-015-0018-0
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author Sun, Hui
Guan, Yuqing
Wang, Lei
Zhao, Yong
Lv, Hong
Bi, Xiuping
Wang, Huating
Zhang, Xuejing
Liu, Li
Wei, Min
Song, Hui
Su, Guohai
author_facet Sun, Hui
Guan, Yuqing
Wang, Lei
Zhao, Yong
Lv, Hong
Bi, Xiuping
Wang, Huating
Zhang, Xuejing
Liu, Li
Wei, Min
Song, Hui
Su, Guohai
author_sort Sun, Hui
collection PubMed
description BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mortality in patients with diabetes is uncertain. METHODS: We performed a meta-analysis of results from randomized controlled trials (RCTs) of the long-term outcome of cardiac resynchronization therapy for heart failure in diabetic and non-diabetic patients. Literature search of MEDLINE via Pubmed for reports of randomized controlled trials of Cardiac resynchronization for chronic symptomatic left-ventricular dysfunction in patients with and without diabetes mellitus, with death as the outcome. Relevant data were analyzed by use of a random-effects model. Reports published from 1994 to 2011 that described RCTs of CRT for treating chronic symptomatic left ventricular dysfunction in patients with and without diabetes, with all-cause mortality as an outcome. RESULTS: A total of 5 randomized controlled trials met the inclusion criteria, for 2,923 patients. The quality of studies was good to moderate. Cardiac resynchronization significantly reduced the mortality for heart failure patients with or without diabetes mellitus. Mortality was 24.3% for diabetic patients with heart failure and 20.4 % for non-diabetics (odds ratio 1.28, 95% confidence interval 1.06–1.55; P = 0.010). CONCLUSIONS: Cardiac resynchronization therapy (CRT) may reduce mortality from progressive heart failure in patients with or without diabetes mellitus, but mortality may be higher for patients with than without diabetes after CRT for heart failure.
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spelling pubmed-44619102015-06-11 Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis Sun, Hui Guan, Yuqing Wang, Lei Zhao, Yong Lv, Hong Bi, Xiuping Wang, Huating Zhang, Xuejing Liu, Li Wei, Min Song, Hui Su, Guohai BMC Cardiovasc Disord Research Article BACKGROUND: Diabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mortality in patients with diabetes is uncertain. METHODS: We performed a meta-analysis of results from randomized controlled trials (RCTs) of the long-term outcome of cardiac resynchronization therapy for heart failure in diabetic and non-diabetic patients. Literature search of MEDLINE via Pubmed for reports of randomized controlled trials of Cardiac resynchronization for chronic symptomatic left-ventricular dysfunction in patients with and without diabetes mellitus, with death as the outcome. Relevant data were analyzed by use of a random-effects model. Reports published from 1994 to 2011 that described RCTs of CRT for treating chronic symptomatic left ventricular dysfunction in patients with and without diabetes, with all-cause mortality as an outcome. RESULTS: A total of 5 randomized controlled trials met the inclusion criteria, for 2,923 patients. The quality of studies was good to moderate. Cardiac resynchronization significantly reduced the mortality for heart failure patients with or without diabetes mellitus. Mortality was 24.3% for diabetic patients with heart failure and 20.4 % for non-diabetics (odds ratio 1.28, 95% confidence interval 1.06–1.55; P = 0.010). CONCLUSIONS: Cardiac resynchronization therapy (CRT) may reduce mortality from progressive heart failure in patients with or without diabetes mellitus, but mortality may be higher for patients with than without diabetes after CRT for heart failure. BioMed Central 2015-03-21 /pmc/articles/PMC4461910/ /pubmed/25880202 http://dx.doi.org/10.1186/s12872-015-0018-0 Text en © Sun et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sun, Hui
Guan, Yuqing
Wang, Lei
Zhao, Yong
Lv, Hong
Bi, Xiuping
Wang, Huating
Zhang, Xuejing
Liu, Li
Wei, Min
Song, Hui
Su, Guohai
Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title_full Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title_fullStr Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title_full_unstemmed Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title_short Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
title_sort influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461910/
https://www.ncbi.nlm.nih.gov/pubmed/25880202
http://dx.doi.org/10.1186/s12872-015-0018-0
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