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Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland

BACKGROUND: Oesophageal carcinoma is a rare disease with often dismal prognosis. Despite multiple trials addressing specific issues, currently, many questions in management remain unanswered. This work aimed to specifically address areas in the management of oesophageal cancer where high level evide...

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Autores principales: Putora, Paul Martin, Bedenne, Laurent, Budach, Wilfried, Eisterer, Wolfgang, Van Der Gaast, Ate, Jäger, Robert, Van Lanschot, J. Jan B., Mariette, Christophe, Schnider, Annelies, Stahl, Michael, Ruhstaller, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461999/
https://www.ncbi.nlm.nih.gov/pubmed/25994051
http://dx.doi.org/10.1186/s13014-015-0418-4
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author Putora, Paul Martin
Bedenne, Laurent
Budach, Wilfried
Eisterer, Wolfgang
Van Der Gaast, Ate
Jäger, Robert
Van Lanschot, J. Jan B.
Mariette, Christophe
Schnider, Annelies
Stahl, Michael
Ruhstaller, Thomas
author_facet Putora, Paul Martin
Bedenne, Laurent
Budach, Wilfried
Eisterer, Wolfgang
Van Der Gaast, Ate
Jäger, Robert
Van Lanschot, J. Jan B.
Mariette, Christophe
Schnider, Annelies
Stahl, Michael
Ruhstaller, Thomas
author_sort Putora, Paul Martin
collection PubMed
description BACKGROUND: Oesophageal carcinoma is a rare disease with often dismal prognosis. Despite multiple trials addressing specific issues, currently, many questions in management remain unanswered. This work aimed to specifically address areas in the management of oesophageal cancer where high level evidence is not available, performing trials is very demanding and for many questions high-level evidence will not be available in the forseeable future. METHODS: Two experts of each national, oesophageal cancer research group from Austria, France, Germany, the Netherlands and Switzerland were asked to provide statements to controversial issues. After an initial survey, further questions were formulated and answered by all experts. The answers were then discussed and qualitatively analysed for consensus and controversy. RESULTS: Topics such as indications for PET-CT, reasons for induction chemotherapy, radiotherapy dose, the choice of definitive chemo-radiotherapy versus surgery in squamous cell cancer, the role of radiotherapy in adenocarcinoma and selected surgical issues were identified as topics of interest and discussed. CONCLUSION: Areas of significant controversy exist in the management of oesophageal cancer, mostly due to high-level evidence. This is not expected to change in the upcoming years. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13014-015-0418-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-44619992015-06-11 Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland Putora, Paul Martin Bedenne, Laurent Budach, Wilfried Eisterer, Wolfgang Van Der Gaast, Ate Jäger, Robert Van Lanschot, J. Jan B. Mariette, Christophe Schnider, Annelies Stahl, Michael Ruhstaller, Thomas Radiat Oncol Research BACKGROUND: Oesophageal carcinoma is a rare disease with often dismal prognosis. Despite multiple trials addressing specific issues, currently, many questions in management remain unanswered. This work aimed to specifically address areas in the management of oesophageal cancer where high level evidence is not available, performing trials is very demanding and for many questions high-level evidence will not be available in the forseeable future. METHODS: Two experts of each national, oesophageal cancer research group from Austria, France, Germany, the Netherlands and Switzerland were asked to provide statements to controversial issues. After an initial survey, further questions were formulated and answered by all experts. The answers were then discussed and qualitatively analysed for consensus and controversy. RESULTS: Topics such as indications for PET-CT, reasons for induction chemotherapy, radiotherapy dose, the choice of definitive chemo-radiotherapy versus surgery in squamous cell cancer, the role of radiotherapy in adenocarcinoma and selected surgical issues were identified as topics of interest and discussed. CONCLUSION: Areas of significant controversy exist in the management of oesophageal cancer, mostly due to high-level evidence. This is not expected to change in the upcoming years. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13014-015-0418-4) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-21 /pmc/articles/PMC4461999/ /pubmed/25994051 http://dx.doi.org/10.1186/s13014-015-0418-4 Text en © Putora et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Putora, Paul Martin
Bedenne, Laurent
Budach, Wilfried
Eisterer, Wolfgang
Van Der Gaast, Ate
Jäger, Robert
Van Lanschot, J. Jan B.
Mariette, Christophe
Schnider, Annelies
Stahl, Michael
Ruhstaller, Thomas
Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title_full Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title_fullStr Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title_full_unstemmed Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title_short Oesophageal cancer: exploring controversies overview of experts’ opinions of Austria, Germany, France, Netherlands and Switzerland
title_sort oesophageal cancer: exploring controversies overview of experts’ opinions of austria, germany, france, netherlands and switzerland
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461999/
https://www.ncbi.nlm.nih.gov/pubmed/25994051
http://dx.doi.org/10.1186/s13014-015-0418-4
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