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Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients

Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested t...

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Autores principales: Mercadillo, Roberto Emmanuele, Galvez, Víctor, Díaz, Rosalinda, Paredes, Lorena, Velázquez-Moctezuma, Javier, Hernandez-Castillo, Carlos R., Fernandez-Ruiz, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462049/
https://www.ncbi.nlm.nih.gov/pubmed/26113822
http://dx.doi.org/10.3389/fpsyt.2015.00090
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author Mercadillo, Roberto Emmanuele
Galvez, Víctor
Díaz, Rosalinda
Paredes, Lorena
Velázquez-Moctezuma, Javier
Hernandez-Castillo, Carlos R.
Fernandez-Ruiz, Juan
author_facet Mercadillo, Roberto Emmanuele
Galvez, Víctor
Díaz, Rosalinda
Paredes, Lorena
Velázquez-Moctezuma, Javier
Hernandez-Castillo, Carlos R.
Fernandez-Ruiz, Juan
author_sort Mercadillo, Roberto Emmanuele
collection PubMed
description Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant’s routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients’ medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients’ testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives’ testimonies indicate patients’ lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients’ alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.
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spelling pubmed-44620492015-06-25 Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients Mercadillo, Roberto Emmanuele Galvez, Víctor Díaz, Rosalinda Paredes, Lorena Velázquez-Moctezuma, Javier Hernandez-Castillo, Carlos R. Fernandez-Ruiz, Juan Front Psychiatry Physiology Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant’s routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients’ medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients’ testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives’ testimonies indicate patients’ lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients’ alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease. Frontiers Media S.A. 2015-06-10 /pmc/articles/PMC4462049/ /pubmed/26113822 http://dx.doi.org/10.3389/fpsyt.2015.00090 Text en Copyright © 2015 Mercadillo, Galvez, Díaz, Paredes, Velázquez-Moctezuma, Hernandez-Castillo and Fernandez-Ruiz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Mercadillo, Roberto Emmanuele
Galvez, Víctor
Díaz, Rosalinda
Paredes, Lorena
Velázquez-Moctezuma, Javier
Hernandez-Castillo, Carlos R.
Fernandez-Ruiz, Juan
Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title_full Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title_fullStr Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title_full_unstemmed Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title_short Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients
title_sort social and cultural elements associated with neurocognitive dysfunctions in spinocerebellar ataxia type 2 patients
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462049/
https://www.ncbi.nlm.nih.gov/pubmed/26113822
http://dx.doi.org/10.3389/fpsyt.2015.00090
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