Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)(8) isomerase evolutionary intermediates from a diverse metagenome

BACKGROUND: Current sequence-based approaches to identify enzyme functional shifts, such as enzyme promiscuity, have proven to be highly dependent on a priori functional knowledge, hampering our ability to reconstruct evolutionary history behind these mechanisms. Hidden Markov Model (HMM) profiles,...

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Detalles Bibliográficos
Autores principales: Noda-García, Lianet, Juárez-Vázquez, Ana L., Ávila-Arcos, María C., Verduzco-Castro, Ernesto A., Montero-Morán, Gabriela, Gaytán, Paul, Carrillo-Tripp, Mauricio, Barona-Gómez, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462073/
https://www.ncbi.nlm.nih.gov/pubmed/26058375
http://dx.doi.org/10.1186/s12862-015-0378-1

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