Cargando…

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms

Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seungjae, Barnhill, Raymond L., Dummer, Reinhard, Dalton, James, Wu, Jianrong, Pappo, Alberto, Bahrami, Armita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462090/ https://www.ncbi.nlm.nih.gov/pubmed/26061100 http://dx.doi.org/10.1038/srep11200

Ejemplares similares

The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing
por: Wu, Gang, et al.
Publicado: (2016)

Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi
por: Fan, Yiping, et al.
Publicado: (2016)

Targeted Long-Read Bisulfite Sequencing Identifies Differences in the TERT Promoter Methylation Profiles between TERT Wild-Type and TERT Mutant Cancer Cells
por: Lee, Seungjae, et al.
Publicado: (2022)

Integrative histopathological and immunophenotypical characterisation of the inflammatory microenvironment in spitzoid melanocytic neoplasms
por: Hillen, Lisa M, et al.
Publicado: (2020)

Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma
por: Seynnaeve, Brittani, et al.
Publicado: (2017)

PRAME immunohistochemistry compared to traditional FISH testing in spitzoid neoplasms and other difficult to diagnose melanocytic neoplasms
por: Warbasse, Elizabeth, et al.
Publicado: (2023)

A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms
por: Hillen, Lisa M., et al.
Publicado: (2020)

Time to reconsider Spitzoid neoplasms?
por: Urso, Carmelo
Publicado: (2016)

Spitzoid Neoplasms: Suggestions from Genomic Aberrations
por: Urso, Carmelo
Publicado: (2018)

Genomic Landscape of Spitzoid Neoplasms Impacting Patient Management
por: Hillen, Lisa M., et al.
Publicado: (2018)

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update
por: Ferrara, Gerardo, et al.
Publicado: (2015)

Spitz nevi and Spitzoid melanomas - Exome sequencing and comparison to conventional melanocytic nevi and melanomas
por: Lazova, Rossitza, et al.
Publicado: (2017)

Next‐generation sequencing improves agreement and accuracy in the diagnosis of Spitz and spitzoid melanocytic lesions
por: Roth, Andrew, et al.
Publicado: (2022)

A Case of Spitzoid Melanoma
por: Kim, Heung Yeol, et al.
Publicado: (2015)

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center
por: Hilbers, Marie-Luise, et al.
Publicado: (2021)

Addendum: Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center
por: Hilbers, Marie-Luise, et al.
Publicado: (2022)

Agminated Spitz naevi or metastatic spitzoid melanoma?
por: van Kester, Marloes Sophia, et al.
Publicado: (2018)

Dermoscopy of eccrine angiomatous hamartoma: The spitzoid pattern
por: Kelati, Awatef, et al.
Publicado: (2018)

Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
por: Herzum, Astrid, et al.
Publicado: (2023)

Metastatic PRAME-Expressing Juvenile Spitzoid Melanoma on the Buttock
por: Muto, Yusuke, et al.
Publicado: (2020)

Spitz Melanoma is a Distinct Subset of Spitzoid Melanoma
por: Raghavan, Shyam, et al.
Publicado: (2020)

Diagnosis and Prognosis of Canine Melanocytic Neoplasms
por: Smedley, Rebecca C., et al.
Publicado: (2022)

Cutaneous Spitzoid Melanoma in Childhood After Acute Lymphocytic Leukemia
por: Bassetti, Beatriz Ferreira do Prado, et al.
Publicado: (2022)

A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child
por: Kim, Jong Yeob, et al.
Publicado: (2012)

A Case Report of Spitzoid Melanoma in a Patient with Breast Cancer
por: Park, Su Jung, et al.
Publicado: (2022)

Expanding spectrum of “spitzoid” lesions: a small series of 4 cases with MAP2K1 mutations
por: Kerckhoffs, K. G. P., et al.
Publicado: (2020)

Association of germline variants in telomere maintenance genes (POT1, TERF2IP, ACD, and TERT) with spitzoid morphology in familial melanoma: A multi-center case series
por: Goldstein, Alisa M., et al.
Publicado: (2023)

A Pediatric Case of Spitzoid Melanoma with Subsequent Large Lymph Node Metastasis
por: Hayashida, Kenji, et al.
Publicado: (2015)

Pediatric spitzoid lesions of the ear: a single-center experience and review of the literature
por: Viglizzo, Gianmaria, et al.
Publicado: (2023)

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation
por: Hegedüs, Luca, et al.
Publicado: (2021)

UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents
por: Liebmann, Alexandra, et al.
Publicado: (2023)

Synchronously diagnosed pre-sacral neurofibroma and cutaneous spitzoid melanoma: a fortuitous association?
por: Fadare, Oluwole, et al.
Publicado: (2004)

Effect of Having Concurrent Mutations on the Degree of Aggressiveness in Patients with Thyroid Cancer Positive for TERT Promoter Mutations
por: Alohali, Sama, et al.
Publicado: (2023)

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system
por: Küsters-Vandevelde, Heidi V. N., et al.
Publicado: (2009)

The Influence of Clinical Information in the Histopathologic Diagnosis of Melanocytic Skin Neoplasms
por: Ferrara, Gerardo, et al.
Publicado: (2009)

Traumatic iridial extrusion mimicking a conjunctival melanocytic neoplasm
por: Zoroquiain, Pablo, et al.
Publicado: (2016)

Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(−/−) mice
por: Zhou, Q-G, et al.
Publicado: (2016)

Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review
por: Bishop, Michael W., et al.
Publicado: (2015)

Little Patients, Big Issues: Something About Rapidly Growing Nodular Spitzoid Lesions in Childhood
por: Marafioti, Ilenia, et al.
Publicado: (2021)

A Spitzoid Tumor dataset with clinical metadata and Whole Slide Images for Deep Learning models
por: Mosquera-Zamudio, Andrés, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kp5shrqv7vopr2najhge5e7pfp