Cargando…
Spatial Separation of Plk1 Phosphorylation and Activity
Polo-like kinase 1 (Plk1) is one of the major kinases controlling mitosis and cell division. Plk1 is first recruited to the centrosome in S phase, then appears on the kinetochores in late G2, and at the end of mitosis, it translocates to the central spindle. Activation of Plk1 requires phosphorylati...
Autores principales: | Bruinsma, Wytse, Aprelia, Melinda, Kool, Jolanda, Macurek, Libor, Lindqvist, Arne, Medema, René H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462105/ https://www.ncbi.nlm.nih.gov/pubmed/26114094 http://dx.doi.org/10.3389/fonc.2015.00132 |
Ejemplares similares
-
Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6
por: Aquino Perez, Cecilia, et al.
Publicado: (2020) -
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
por: Silva Cascales, Helena, et al.
Publicado: (2021) -
Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora
por: Bruinsma, W, et al.
Publicado: (2017) -
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer
por: Medema, René H., et al.
Publicado: (2011) -
Residual Cdk1/2 activity after DNA damage promotes senescence
por: Müllers, Erik, et al.
Publicado: (2017)