A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor

BACKGROUND: Estrogen receptors alpha and beta (ERα and ERβ) differentially activate genes with AP-1 elements. ERα activates AP-1 targets via activation functions with estrogens (the AF-dependent pathway), whereas ERβ, and a short version of ERα (ERα DBD-LBD) activate only with anti-estrogens (AF-ind...

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Detalles Bibliográficos
Autores principales: Uht, Rosalie M, Webb, Paul, Nguyen, Phuong, Price Jr, Richard H, Valentine, Cathleen, Favre, Helene, Kushner, Peter J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC446215/
https://www.ncbi.nlm.nih.gov/pubmed/15132742
http://dx.doi.org/10.1186/1478-1336-2-2

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