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Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery

OBJECTIVE: The objective of this study was to assess the outcome of osteochondral allograft (OCA) transplantation as a salvage procedure after various cartilage repair surgeries. DESIGN: One hundred sixty-four knees in 163 patients (mean age = 32.6 years; range = 11-59 years; 55% males) were treated...

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Autores principales: Gracitelli, Guilherme C., Meric, Gokhan, Pulido, Pamela A., McCauley, Julie C., Bugbee, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462254/
https://www.ncbi.nlm.nih.gov/pubmed/26069712
http://dx.doi.org/10.1177/1947603514566298
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author Gracitelli, Guilherme C.
Meric, Gokhan
Pulido, Pamela A.
McCauley, Julie C.
Bugbee, William D.
author_facet Gracitelli, Guilherme C.
Meric, Gokhan
Pulido, Pamela A.
McCauley, Julie C.
Bugbee, William D.
author_sort Gracitelli, Guilherme C.
collection PubMed
description OBJECTIVE: The objective of this study was to assess the outcome of osteochondral allograft (OCA) transplantation as a salvage procedure after various cartilage repair surgeries. DESIGN: One hundred sixty-four knees in 163 patients (mean age = 32.6 years; range = 11-59 years; 55% males) were treated with OCA transplantation after subchondral marrow stimulation (SMS), osteochondral autograft transplantation (OAT), and autologous chondrocyte implantation (ACI). The majority of previous procedures were isolated SMS in 145 knees (88.4%). Mean allograft size was 8.5 ± 7.9 cm(2). The most common location was in femoral condyle. The number and type of reoperations on the operative knee were assessed. Failure of the OCA transplantation was defined as any reoperation resulting in removal of the allograft. Functional outcomes were evaluated. RESULTS: Sixty-eight knees had reoperations after OCA transplantation. Thirty-one knees (18.9%) were classified as allograft failures. The median time to failure was 2.6 ± 6.8 years (range = 0.7-23.4 years). Survivorship of the graft was 82% at 10 years and 74.9% at 15 years. Patients whose grafts were still in situ had a mean of 8.5 ± 5.6 years of follow-up. Scores on all functional outcomes scales improved significantly from preoperatively to latest follow-up. Eighty-nine percent of OCA transplantation patients reported being “extremely satisfied” or “satisfied.” CONCLUSION: Despite the high reoperation rate, OCA transplantation is a successful salvage surgical treatment after cartilage repair procedures. This cohort showed improved survivorship and functional outcomes of OCA transplantation after SMS, ACI, and OAT.
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spelling pubmed-44622542016-04-01 Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery Gracitelli, Guilherme C. Meric, Gokhan Pulido, Pamela A. McCauley, Julie C. Bugbee, William D. Cartilage Article OBJECTIVE: The objective of this study was to assess the outcome of osteochondral allograft (OCA) transplantation as a salvage procedure after various cartilage repair surgeries. DESIGN: One hundred sixty-four knees in 163 patients (mean age = 32.6 years; range = 11-59 years; 55% males) were treated with OCA transplantation after subchondral marrow stimulation (SMS), osteochondral autograft transplantation (OAT), and autologous chondrocyte implantation (ACI). The majority of previous procedures were isolated SMS in 145 knees (88.4%). Mean allograft size was 8.5 ± 7.9 cm(2). The most common location was in femoral condyle. The number and type of reoperations on the operative knee were assessed. Failure of the OCA transplantation was defined as any reoperation resulting in removal of the allograft. Functional outcomes were evaluated. RESULTS: Sixty-eight knees had reoperations after OCA transplantation. Thirty-one knees (18.9%) were classified as allograft failures. The median time to failure was 2.6 ± 6.8 years (range = 0.7-23.4 years). Survivorship of the graft was 82% at 10 years and 74.9% at 15 years. Patients whose grafts were still in situ had a mean of 8.5 ± 5.6 years of follow-up. Scores on all functional outcomes scales improved significantly from preoperatively to latest follow-up. Eighty-nine percent of OCA transplantation patients reported being “extremely satisfied” or “satisfied.” CONCLUSION: Despite the high reoperation rate, OCA transplantation is a successful salvage surgical treatment after cartilage repair procedures. This cohort showed improved survivorship and functional outcomes of OCA transplantation after SMS, ACI, and OAT. SAGE Publications 2015-04 /pmc/articles/PMC4462254/ /pubmed/26069712 http://dx.doi.org/10.1177/1947603514566298 Text en © The Author(s) 2015
spellingShingle Article
Gracitelli, Guilherme C.
Meric, Gokhan
Pulido, Pamela A.
McCauley, Julie C.
Bugbee, William D.
Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title_full Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title_fullStr Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title_full_unstemmed Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title_short Osteochondral Allograft Transplantation for Knee Lesions after Failure of Cartilage Repair Surgery
title_sort osteochondral allograft transplantation for knee lesions after failure of cartilage repair surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462254/
https://www.ncbi.nlm.nih.gov/pubmed/26069712
http://dx.doi.org/10.1177/1947603514566298
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