Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors

Mutant mouse models are indispensable tools for clarifying gene functions and elucidating the pathogenic mechanisms of human diseases. Here, we describe novel cancer models bearing point mutations in the retinoblastoma gene (Rb1) generated by N-ethyl-N-nitrosourea mutagenesis. Two mutations in splic...

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Detalles Bibliográficos
Autores principales: Toki, Hideaki, Inoue, Maki, Minowa, Osamu, Motegi, Hiromi, Saiki, Yuriko, Wakana, Shigeharu, Masuya, Hiroshi, Gondo, Yoichi, Shiroishi, Toshihiko, Yao, Ryoji, Noda, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462357/
https://www.ncbi.nlm.nih.gov/pubmed/25088905
http://dx.doi.org/10.1111/cas.12495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462357/
https://www.ncbi.nlm.nih.gov/pubmed/25088905
http://dx.doi.org/10.1111/cas.12495

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