Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions

We previously established that COX-2 overexpression promotes breast cancer progression and metastasis. As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), downstream of COX-2. Here we used the...

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Detalles Bibliográficos
Autores principales: Majumder, Mousumi, Xin, Xiping, Liu, Ling, Girish, Gannareddy V, Lala, Peeyush K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462388/
https://www.ncbi.nlm.nih.gov/pubmed/24981602
http://dx.doi.org/10.1111/cas.12475

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