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Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux

OBJECTIVES: The objective of this study was to asses the prevalence of atrophic gastritis in children. We also wanted to compare the clinical manifestation, endoscopic appearance and the degree of the gastric atrophy in children and to identify the possible causes which determine gastric atrophy. ME...

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Autores principales: SLĂVESCU, KINGA CRISTINA, MĂRGESCU, CAMELIA, PÎRVAN, ALEXANDRU, ŞARBAN, COSTICĂ, GHEBAN, DAN, MIU, NICOLAE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iuliu Hatieganu University of Medicine and Pharmacy 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462443/
https://www.ncbi.nlm.nih.gov/pubmed/26527935
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author SLĂVESCU, KINGA CRISTINA
MĂRGESCU, CAMELIA
PÎRVAN, ALEXANDRU
ŞARBAN, COSTICĂ
GHEBAN, DAN
MIU, NICOLAE
author_facet SLĂVESCU, KINGA CRISTINA
MĂRGESCU, CAMELIA
PÎRVAN, ALEXANDRU
ŞARBAN, COSTICĂ
GHEBAN, DAN
MIU, NICOLAE
author_sort SLĂVESCU, KINGA CRISTINA
collection PubMed
description OBJECTIVES: The objective of this study was to asses the prevalence of atrophic gastritis in children. We also wanted to compare the clinical manifestation, endoscopic appearance and the degree of the gastric atrophy in children and to identify the possible causes which determine gastric atrophy. METHODS: We evaluated 247 children with chronic gastritis (153 female/94 male, mean age 12.32 years). Atrophy was defined as the loss of normal glandular components, including replacement with fibrosis and/or intestinal metaplasia. RESULTS: The prevalence of the atrophic gastritis was 16.6% (41 cases), mean age 11.59+/−1.75 years, male-to-female ratio 16:25. The clinical manifestations were correlated with the patient age (infants and toddlers were evaluated mostly for weight loss – 4 cases, and older children for abdominal pain – 22 cases). The endoscopic appearance was described as either nodular (15 cases), or erythematous gastritis (10 cases), or normal (10 cases). According to the Sydney System, the degree of atrophy was found to be mild in 3 patients, moderate in 25, and severe in 13 patients; 14 cases were associated with duodenogastric reflux, 5 with Helicobacter pylori and 2 with Helicobacter heilmannii infection, but in 17 cases the etiology was unknown. CONCLUSIONS: Atrophic gastritis is present in childhood, even at very young ages (infants, toddlers). The endoscopic appearance is not characteristic for the presence of atrophy. The degree of the atrophy is not correlated with the age of the children. Because of the relatively high number of duodenogastric reflux associated with gastric atrophy, further studies need to evaluate the potential causes and clinical course.
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spelling pubmed-44624432015-11-02 Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux SLĂVESCU, KINGA CRISTINA MĂRGESCU, CAMELIA PÎRVAN, ALEXANDRU ŞARBAN, COSTICĂ GHEBAN, DAN MIU, NICOLAE Clujul Med Original Research OBJECTIVES: The objective of this study was to asses the prevalence of atrophic gastritis in children. We also wanted to compare the clinical manifestation, endoscopic appearance and the degree of the gastric atrophy in children and to identify the possible causes which determine gastric atrophy. METHODS: We evaluated 247 children with chronic gastritis (153 female/94 male, mean age 12.32 years). Atrophy was defined as the loss of normal glandular components, including replacement with fibrosis and/or intestinal metaplasia. RESULTS: The prevalence of the atrophic gastritis was 16.6% (41 cases), mean age 11.59+/−1.75 years, male-to-female ratio 16:25. The clinical manifestations were correlated with the patient age (infants and toddlers were evaluated mostly for weight loss – 4 cases, and older children for abdominal pain – 22 cases). The endoscopic appearance was described as either nodular (15 cases), or erythematous gastritis (10 cases), or normal (10 cases). According to the Sydney System, the degree of atrophy was found to be mild in 3 patients, moderate in 25, and severe in 13 patients; 14 cases were associated with duodenogastric reflux, 5 with Helicobacter pylori and 2 with Helicobacter heilmannii infection, but in 17 cases the etiology was unknown. CONCLUSIONS: Atrophic gastritis is present in childhood, even at very young ages (infants, toddlers). The endoscopic appearance is not characteristic for the presence of atrophy. The degree of the atrophy is not correlated with the age of the children. Because of the relatively high number of duodenogastric reflux associated with gastric atrophy, further studies need to evaluate the potential causes and clinical course. Iuliu Hatieganu University of Medicine and Pharmacy 2013 2013-05-09 /pmc/articles/PMC4462443/ /pubmed/26527935 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Original Research
SLĂVESCU, KINGA CRISTINA
MĂRGESCU, CAMELIA
PÎRVAN, ALEXANDRU
ŞARBAN, COSTICĂ
GHEBAN, DAN
MIU, NICOLAE
Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title_full Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title_fullStr Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title_full_unstemmed Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title_short Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux
title_sort atrophic gastritis: helicobacter pylori versus duodenogastric reflux
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462443/
https://www.ncbi.nlm.nih.gov/pubmed/26527935
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