Cargando…

Synthesis and Biological Evaluation of 3-Alkyl-1,5-Diaryl-1H-Pyrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative Activity

A series of novel 3-alkyl-1,5-diaryl-1H-pyrazoles were synthesized as combretastatin A-4 (CA-4) analogues and evaluated for antiproliferative activity against three human cancer cell lines (SGC-7901, A549 and HT-1080). Most of the target compounds displayed moderate to potent antiproliferative activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Qile, Qi, Huan, Sun, Maolin, Zuo, Daiying, Jiang, Xuewei, Wen, Zhiyong, Wang, Zhiwei, Wu, Yingliang, Zhang, Weige
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462585/ https://www.ncbi.nlm.nih.gov/pubmed/26061410 http://dx.doi.org/10.1371/journal.pone.0128710

Ejemplares similares

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
por: Sun, Maolin, et al.
Publicado: (2017)

Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues
por: Wen, Zhiyong, et al.
Publicado: (2016)

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies
por: Egharevba, Godshelp O., et al.
Publicado: (2022)

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors
por: Xu, Qile, et al.
Publicado: (2017)

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues
por: do Amaral, Daniel Nascimento, et al.
Publicado: (2014)

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues
por: Fayad, Eman, et al.
Publicado: (2023)

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers
por: Kovács, Édua, et al.
Publicado: (2023)

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4
por: Malebari, Azizah M., et al.
Publicado: (2021)

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
por: Zaki, Islam, et al.
Publicado: (2022)

3D-QSAR Study of Combretastatin A-4 Analogs Based on Molecular Docking
por: Jin, Yinghua, et al.
Publicado: (2011)

Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors
por: Kumar, Sunil, et al.
Publicado: (2013)

Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins
por: Lipeeva, Alla V., et al.
Publicado: (2014)

Synthesis and photophysical investigations of pyridine-pyrazolate bound boron(III) diaryl complexes
por: Javaid, Rashid, et al.
Publicado: (2022)

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
por: de Lima Neto, Jorge, et al.
Publicado: (2023)

Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones
por: Arenas, Paola, et al.
Publicado: (2013)

Synthesis of novel natural product-like diaryl acetylenes as hypoxia inducible factor-1 inhibitors and antiproliferative agents
por: Wang, Shisheng, et al.
Publicado: (2019)

Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors
por: Wu, Yue, et al.
Publicado: (2017)

Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility
por: Chen, Zhi-Hao, et al.
Publicado: (2023)

Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with In Vitro Growth Inhibitory and In Vivo Antitumor Activity
por: Turanlı, Sümeyye, et al.
Publicado: (2022)

Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides
por: Oliveira, Simone, et al.
Publicado: (2014)

Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
por: Ma, Yihui, et al.
Publicado: (2022)

A Novel Fluorescence Sensor for Iodide Detection Based on the 1,3-Diaryl Pyrazole Unit with AIE and Mechanochromic Fluorescence Behavior
por: Deng, Lili, et al.
Publicado: (2023)

Design and Synthesis of Novel Dehydroepiandrosterone Analogues as Potent Antiproliferative Agents
por: Huang, Xing, et al.
Publicado: (2018)

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
por: Yang, Yiwen, et al.
Publicado: (2011)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy
por: Li, Yanchun, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
por: Zheng, Shilong, et al.
Publicado: (2014)

Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents
por: Song, Ming-Yu, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers
por: Wang, Chao, et al.
Publicado: (2021)

Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents
por: Duan, Yong-Tao, et al.
Publicado: (2016)

Design and Synthesis of Fluorescent 1,3-Diaryl-β-carbolines and 1,3-Diaryl-3,4-dihydro-β-carbolines
por: Pu, JiYang, et al.
Publicado: (2021)

6,N(2)-Diaryl-1,3,5-triazine-2,4-diamines: synthesis, antiproliferative activity and 3D-QSAR modeling
por: Junaid, Ahmad, et al.
Publicado: (2020)

Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides
por: Kobiki, Yohsuke, et al.
Publicado: (2013)

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers
por: Liu, Zi, et al.
Publicado: (2022)

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
por: Özdemir, Ahmet, et al.
Publicado: (2015)

An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells in vitro
por: Abodo Onambele, Liliane, et al.
Publicado: (2022)

The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4
por: Su, Min, et al.
Publicado: (2016)

Homocouplings of Sodium Arenesulfinates: Selective Access to Symmetric Diaryl Sulfides and Diaryl Disulfides
por: Yu, Xin-Zhang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ci1pep3gagkfivml19fpugtbbq