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Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer
PURPOSE: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy co...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Urological Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462633/ https://www.ncbi.nlm.nih.gov/pubmed/26078840 http://dx.doi.org/10.4111/kju.2015.56.6.435 |
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author | Taverna, Gianluigi Grizzi, Fabio Colombo, Piergiuseppe Seveso, Mauro Giusti, Guido Proietti, Silvia Fiorini, Girolamo Lughezzani, Giovanni Casale, Paolo Buffi, Nicolò Lazzari, Massimo Guazzoni, Giorgio |
author_facet | Taverna, Gianluigi Grizzi, Fabio Colombo, Piergiuseppe Seveso, Mauro Giusti, Guido Proietti, Silvia Fiorini, Girolamo Lughezzani, Giovanni Casale, Paolo Buffi, Nicolò Lazzari, Massimo Guazzoni, Giorgio |
author_sort | Taverna, Gianluigi |
collection | PubMed |
description | PURPOSE: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma. MATERIALS AND METHODS: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsy sampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-µm sections were treated with CD34 antibodies and were digitized by using an image analysis system that automatically estimates the surface fractal dimension. RESULTS: Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlations were found between the vascular surface fractal dimension and patient's age, PSA and free-to-total PSA ratios, pathological stage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence. CONCLUSIONS: The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancer tissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmark of intermediate- and high-risk prostate cancer. |
format | Online Article Text |
id | pubmed-4462633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-44626332015-06-15 Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer Taverna, Gianluigi Grizzi, Fabio Colombo, Piergiuseppe Seveso, Mauro Giusti, Guido Proietti, Silvia Fiorini, Girolamo Lughezzani, Giovanni Casale, Paolo Buffi, Nicolò Lazzari, Massimo Guazzoni, Giorgio Korean J Urol Original Article PURPOSE: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma. MATERIALS AND METHODS: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsy sampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-µm sections were treated with CD34 antibodies and were digitized by using an image analysis system that automatically estimates the surface fractal dimension. RESULTS: Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlations were found between the vascular surface fractal dimension and patient's age, PSA and free-to-total PSA ratios, pathological stage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence. CONCLUSIONS: The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancer tissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmark of intermediate- and high-risk prostate cancer. The Korean Urological Association 2015-06 2015-06-02 /pmc/articles/PMC4462633/ /pubmed/26078840 http://dx.doi.org/10.4111/kju.2015.56.6.435 Text en © The Korean Urological Association, 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Taverna, Gianluigi Grizzi, Fabio Colombo, Piergiuseppe Seveso, Mauro Giusti, Guido Proietti, Silvia Fiorini, Girolamo Lughezzani, Giovanni Casale, Paolo Buffi, Nicolò Lazzari, Massimo Guazzoni, Giorgio Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title | Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title_full | Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title_fullStr | Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title_full_unstemmed | Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title_short | Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
title_sort | two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462633/ https://www.ncbi.nlm.nih.gov/pubmed/26078840 http://dx.doi.org/10.4111/kju.2015.56.6.435 |
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