4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluated in vitro. Two curcumin-biphenyl derivatives showed interesting growth inhibitory activit...

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Autores principales: Dettori, Maria Antonietta, Fabbri, Davide, Pisano, Marina, Rozzo, Carla, Palmieri, Giuseppe, Dessµ, Alessandro, Dallocchio, Roberto, Delogu, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462845/
https://www.ncbi.nlm.nih.gov/pubmed/26074750
http://dx.doi.org/10.2174/1570180811666140915222343
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author Dettori, Maria Antonietta
Fabbri, Davide
Pisano, Marina
Rozzo, Carla
Palmieri, Giuseppe
Dessµ, Alessandro
Dallocchio, Roberto
Delogu, Giovanna
author_facet Dettori, Maria Antonietta
Fabbri, Davide
Pisano, Marina
Rozzo, Carla
Palmieri, Giuseppe
Dessµ, Alessandro
Dallocchio, Roberto
Delogu, Giovanna
author_sort Dettori, Maria Antonietta
collection PubMed
description A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluated in vitro. Two curcumin-biphenyl derivatives showed interesting growth inhibitory activities on different malignant melanoma cell lines with IC(50) ranging from 13 to 1 µM. Preliminary molecular modeling studies were carried out to evaluate conformations and dihedral angles suitable for antiproliferative activity in hydroxylated biphenyls bearing a side aliphatic chain.
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spelling pubmed-44628452015-06-12 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls Dettori, Maria Antonietta Fabbri, Davide Pisano, Marina Rozzo, Carla Palmieri, Giuseppe Dessµ, Alessandro Dallocchio, Roberto Delogu, Giovanna Lett Drug Des Discov Article A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluated in vitro. Two curcumin-biphenyl derivatives showed interesting growth inhibitory activities on different malignant melanoma cell lines with IC(50) ranging from 13 to 1 µM. Preliminary molecular modeling studies were carried out to evaluate conformations and dihedral angles suitable for antiproliferative activity in hydroxylated biphenyls bearing a side aliphatic chain. Bentham Science Publishers 2015-02 2015-02 /pmc/articles/PMC4462845/ /pubmed/26074750 http://dx.doi.org/10.2174/1570180811666140915222343 Text en ©2015 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Dettori, Maria Antonietta
Fabbri, Davide
Pisano, Marina
Rozzo, Carla
Palmieri, Giuseppe
Dessµ, Alessandro
Dallocchio, Roberto
Delogu, Giovanna
4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title_full 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title_fullStr 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title_full_unstemmed 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title_short 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls
title_sort 4-substituted-2-methoxyphenol: suitable building block to prepare new bioactive natural-like hydroxylated biphenyls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462845/
https://www.ncbi.nlm.nih.gov/pubmed/26074750
http://dx.doi.org/10.2174/1570180811666140915222343
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