The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans

Bacteria often thrive in natural environments through a sessile mode of growth, known as the biofilm. Biofilms are well-structured communities and their formation is tightly regulated. However, the mechanisms by which interspecies interactions alter the formation of biofilms have not yet been elucid...

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Detalles Bibliográficos
Autores principales: Inaba, Tomohiro, Oura, Hiromu, Morinaga, Kana, Toyofuku, Masanori, Nomura, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Japanese Society of Microbial Ecology (JSME)/the Japanese Society of Soil Microbiology (JSSM)/the Taiwan Society of Microbial Ecology (TSME)/the Japanese Society of Plant Microbe Interactions (JSPMI) 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462930/
https://www.ncbi.nlm.nih.gov/pubmed/25854411
http://dx.doi.org/10.1264/jsme2.ME14140
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author Inaba, Tomohiro
Oura, Hiromu
Morinaga, Kana
Toyofuku, Masanori
Nomura, Nobuhiko
author_facet Inaba, Tomohiro
Oura, Hiromu
Morinaga, Kana
Toyofuku, Masanori
Nomura, Nobuhiko
author_sort Inaba, Tomohiro
collection PubMed
description Bacteria often thrive in natural environments through a sessile mode of growth, known as the biofilm. Biofilms are well-structured communities and their formation is tightly regulated. However, the mechanisms by which interspecies interactions alter the formation of biofilms have not yet been elucidated in detail. We herein demonstrated that a quorum-sensing signal in Pseudomonas aeruginosa (the Pseudomonas quinolone signal; PQS) inhibited biofilm formation by Streptococcus mutans. Although the PQS did not affect cell growth, biofilm formation was markedly inhibited. Our results revealed a unique role for this multifunctional PQS and also indicated its application in the development of prophylactic agents against caries-causing S. mutans.
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spelling pubmed-44629302015-06-19 The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans Inaba, Tomohiro Oura, Hiromu Morinaga, Kana Toyofuku, Masanori Nomura, Nobuhiko Microbes Environ Short Communication Bacteria often thrive in natural environments through a sessile mode of growth, known as the biofilm. Biofilms are well-structured communities and their formation is tightly regulated. However, the mechanisms by which interspecies interactions alter the formation of biofilms have not yet been elucidated in detail. We herein demonstrated that a quorum-sensing signal in Pseudomonas aeruginosa (the Pseudomonas quinolone signal; PQS) inhibited biofilm formation by Streptococcus mutans. Although the PQS did not affect cell growth, biofilm formation was markedly inhibited. Our results revealed a unique role for this multifunctional PQS and also indicated its application in the development of prophylactic agents against caries-causing S. mutans. the Japanese Society of Microbial Ecology (JSME)/the Japanese Society of Soil Microbiology (JSSM)/the Taiwan Society of Microbial Ecology (TSME)/the Japanese Society of Plant Microbe Interactions (JSPMI) 2015-06 2015-04-09 /pmc/articles/PMC4462930/ /pubmed/25854411 http://dx.doi.org/10.1264/jsme2.ME14140 Text en Copyright 2015 by Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Inaba, Tomohiro
Oura, Hiromu
Morinaga, Kana
Toyofuku, Masanori
Nomura, Nobuhiko
The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title_full The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title_fullStr The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title_full_unstemmed The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title_short The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
title_sort pseudomonas quinolone signal inhibits biofilm development of streptococcus mutans
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462930/
https://www.ncbi.nlm.nih.gov/pubmed/25854411
http://dx.doi.org/10.1264/jsme2.ME14140
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