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The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation

Cholera toxin (CT) intoxicates cells by trafficking from the cell surface to the endoplasmic reticulum (ER), where the catalytic CTA1 subunit hijacks components of the ER-associated degradation (ERAD) machinery to retrotranslocate to the cytosol and induce toxicity. In the ER, CT targets to the ERAD...

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Detalles Bibliográficos
Autores principales:	Williams, Jeffrey M., Inoue, Takamasa, Chen, Grace, Tsai, Billy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462937/ https://www.ncbi.nlm.nih.gov/pubmed/25877869 http://dx.doi.org/10.1091/mbc.E15-01-0014

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