Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism

Simple-type epithelial keratins are intermediate filament proteins important for mechanical stability and stress protection. Keratin mutations predispose to human liver disorders, whereas their roles in intestinal diseases are unclear. Absence of keratin 8 (K8) in mice leads to colitis, decreased Na...

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Detalles Bibliográficos
Autores principales: Helenius, Terhi O., Misiorek, Julia O., Nyström, Joel H., Fortelius, Lina E., Habtezion, Aida, Liao, Jian, Asghar, M. Nadeem, Zhang, Haiyan, Azhar, Salman, Omary, M. Bishr, Toivola, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462946/
https://www.ncbi.nlm.nih.gov/pubmed/25904331
http://dx.doi.org/10.1091/mbc.E14-02-0736

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