Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis

Background. Antibiotic-tolerant bacterial persistence prevents treatment shortening in drug-susceptible tuberculosis, and accumulation of intracellular lipid bodies has been proposed to identify a persister phenotype of Mycobacterium tuberculosis cells. In Malawi, we modeled bacillary elimination ra...

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Detalles Bibliográficos
Autores principales: Sloan, Derek J., Mwandumba, Henry C., Garton, Natalie J., Khoo, Saye H., Butterworth, Anthony E., Allain, Theresa J., Heyderman, Robert S., Corbett, Elizabeth L., Barer, Mike R., Davies, Geraint R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463005/
https://www.ncbi.nlm.nih.gov/pubmed/25778753
http://dx.doi.org/10.1093/cid/civ195

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