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miRNAs in the Pathogenesis of Systemic Lupus Erythematosus
MicroRNAs (miRNAs) were first discovered as regulatory RNAs that controlled the timing of the larval development of Caenorhabditis elegans. Since then, nearly 30,000 mature miRNA products have been found in many species, including plants, warms, flies and mammals. Currently, miRNAs are well establis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463604/ https://www.ncbi.nlm.nih.gov/pubmed/25927578 http://dx.doi.org/10.3390/ijms16059557 |
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author | Qu, Bo Shen, Nan |
author_facet | Qu, Bo Shen, Nan |
author_sort | Qu, Bo |
collection | PubMed |
description | MicroRNAs (miRNAs) were first discovered as regulatory RNAs that controlled the timing of the larval development of Caenorhabditis elegans. Since then, nearly 30,000 mature miRNA products have been found in many species, including plants, warms, flies and mammals. Currently, miRNAs are well established as endogenous small (~22 nt) noncoding RNAs, which have functions in regulating mRNA stability and translation. Owing to intensive investigations during the last decade, miRNAs were found to play essential roles in regulating many physiological and pathological processes. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by elevated autoantibodies against nuclear antigens and excessive inflammatory responses affecting multiple organs. Although efforts were taken and theories were produced to elucidate the pathogenesis of SLE, we still lack sufficient knowledge about the disease for developing effective therapies for lupus patients. Recent advances indicate that miRNAs are involved in the development of SLE, which gives us new insights into the pathogenesis of SLE and might lead to the finding of new therapeutic targets. Here, we will review recent discoveries about how miRNAs are involved in the pathogenesis of SLE and how it can promote the development of new therapy. |
format | Online Article Text |
id | pubmed-4463604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44636042015-06-16 miRNAs in the Pathogenesis of Systemic Lupus Erythematosus Qu, Bo Shen, Nan Int J Mol Sci Review MicroRNAs (miRNAs) were first discovered as regulatory RNAs that controlled the timing of the larval development of Caenorhabditis elegans. Since then, nearly 30,000 mature miRNA products have been found in many species, including plants, warms, flies and mammals. Currently, miRNAs are well established as endogenous small (~22 nt) noncoding RNAs, which have functions in regulating mRNA stability and translation. Owing to intensive investigations during the last decade, miRNAs were found to play essential roles in regulating many physiological and pathological processes. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by elevated autoantibodies against nuclear antigens and excessive inflammatory responses affecting multiple organs. Although efforts were taken and theories were produced to elucidate the pathogenesis of SLE, we still lack sufficient knowledge about the disease for developing effective therapies for lupus patients. Recent advances indicate that miRNAs are involved in the development of SLE, which gives us new insights into the pathogenesis of SLE and might lead to the finding of new therapeutic targets. Here, we will review recent discoveries about how miRNAs are involved in the pathogenesis of SLE and how it can promote the development of new therapy. MDPI 2015-04-28 /pmc/articles/PMC4463604/ /pubmed/25927578 http://dx.doi.org/10.3390/ijms16059557 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Qu, Bo Shen, Nan miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title | miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title_full | miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title_fullStr | miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title_full_unstemmed | miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title_short | miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |
title_sort | mirnas in the pathogenesis of systemic lupus erythematosus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463604/ https://www.ncbi.nlm.nih.gov/pubmed/25927578 http://dx.doi.org/10.3390/ijms16059557 |
work_keys_str_mv | AT qubo mirnasinthepathogenesisofsystemiclupuserythematosus AT shennan mirnasinthepathogenesisofsystemiclupuserythematosus |