Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization

This article reviews recent developments in microfluidic impedance flow cytometry for high-throughput electrical property characterization of single cells. Four major perspectives of microfluidic impedance flow cytometry for single-cell characterization are included in this review: (1) early develop...

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Detalles Bibliográficos
Autores principales: Chen, Jian, Xue, Chengcheng, Zhao, Yang, Chen, Deyong, Wu, Min-Hsien, Wang, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463619/
https://www.ncbi.nlm.nih.gov/pubmed/25938973
http://dx.doi.org/10.3390/ijms16059804
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author Chen, Jian
Xue, Chengcheng
Zhao, Yang
Chen, Deyong
Wu, Min-Hsien
Wang, Junbo
author_facet Chen, Jian
Xue, Chengcheng
Zhao, Yang
Chen, Deyong
Wu, Min-Hsien
Wang, Junbo
author_sort Chen, Jian
collection PubMed
description This article reviews recent developments in microfluidic impedance flow cytometry for high-throughput electrical property characterization of single cells. Four major perspectives of microfluidic impedance flow cytometry for single-cell characterization are included in this review: (1) early developments of microfluidic impedance flow cytometry for single-cell electrical property characterization; (2) microfluidic impedance flow cytometry with enhanced sensitivity; (3) microfluidic impedance and optical flow cytometry for single-cell analysis and (4) integrated point of care system based on microfluidic impedance flow cytometry. We examine the advantages and limitations of each technique and discuss future research opportunities from the perspectives of both technical innovation and clinical applications.
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spelling pubmed-44636192015-06-16 Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization Chen, Jian Xue, Chengcheng Zhao, Yang Chen, Deyong Wu, Min-Hsien Wang, Junbo Int J Mol Sci Review This article reviews recent developments in microfluidic impedance flow cytometry for high-throughput electrical property characterization of single cells. Four major perspectives of microfluidic impedance flow cytometry for single-cell characterization are included in this review: (1) early developments of microfluidic impedance flow cytometry for single-cell electrical property characterization; (2) microfluidic impedance flow cytometry with enhanced sensitivity; (3) microfluidic impedance and optical flow cytometry for single-cell analysis and (4) integrated point of care system based on microfluidic impedance flow cytometry. We examine the advantages and limitations of each technique and discuss future research opportunities from the perspectives of both technical innovation and clinical applications. MDPI 2015-04-29 /pmc/articles/PMC4463619/ /pubmed/25938973 http://dx.doi.org/10.3390/ijms16059804 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Jian
Xue, Chengcheng
Zhao, Yang
Chen, Deyong
Wu, Min-Hsien
Wang, Junbo
Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title_full Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title_fullStr Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title_full_unstemmed Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title_short Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization
title_sort microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463619/
https://www.ncbi.nlm.nih.gov/pubmed/25938973
http://dx.doi.org/10.3390/ijms16059804
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