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Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors

A series of 1,4-disubstituted-3,4-dihydroisoquinoline derivatives designed as tubulin polymerization inhibitors were synthesized. Their cytotoxic activities against the CEM leukemia cell line were evaluated. Most of them displayed moderate cytotoxic activities, and compounds 21 and 32 showed good ac...

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Detalles Bibliográficos
Autores principales:	Zhang, Ling, Song, Yunlong, Huang, Jingjing, Liu, Jia, Zhu, Wenwen, Zhou, Youjun, Lv, Jiaguo, Zheng, Canhui, Zhu, Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463639/ https://www.ncbi.nlm.nih.gov/pubmed/25950763 http://dx.doi.org/10.3390/ijms160510173

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