Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic scheme...

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Detalles Bibliográficos
Autores principales: Lathuilière, Aurélien, Mach, Nicolas, Schneider, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463663/
https://www.ncbi.nlm.nih.gov/pubmed/26006227
http://dx.doi.org/10.3390/ijms160510578
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author Lathuilière, Aurélien
Mach, Nicolas
Schneider, Bernard L.
author_facet Lathuilière, Aurélien
Mach, Nicolas
Schneider, Bernard L.
author_sort Lathuilière, Aurélien
collection PubMed
description Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines.
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spelling pubmed-44636632015-06-16 Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System Lathuilière, Aurélien Mach, Nicolas Schneider, Bernard L. Int J Mol Sci Review Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines. MDPI 2015-05-08 /pmc/articles/PMC4463663/ /pubmed/26006227 http://dx.doi.org/10.3390/ijms160510578 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lathuilière, Aurélien
Mach, Nicolas
Schneider, Bernard L.
Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title_full Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title_fullStr Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title_full_unstemmed Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title_short Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
title_sort encapsulated cellular implants for recombinant protein delivery and therapeutic modulation of the immune system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463663/
https://www.ncbi.nlm.nih.gov/pubmed/26006227
http://dx.doi.org/10.3390/ijms160510578
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