Cargando…

Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone

Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been reported for their wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Xuejing, Peng, Zhangxiao, Su, Changqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463681/ https://www.ncbi.nlm.nih.gov/pubmed/25984608 http://dx.doi.org/10.3390/ijms160510888

Ejemplares similares

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway
por: Peng, Zhangxiao, et al.
Publicado: (2017)

Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide
por: Scarponi, Claudia, et al.
Publicado: (2014)

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation
por: Butturini, Elena, et al.
Publicado: (2011)

(−)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo
por: Chen, Yuwen, et al.
Publicado: (2018)

Investigation of Molecular Mechanisms Involved in Sensitivity to the Anti-Cancer Activity of Costunolide in Breast Cancer Cells
por: Choi, Yu-Jeong, et al.
Publicado: (2023)

Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential
por: Kim, Dae Yong, et al.
Publicado: (2019)

Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways
por: Wang, Chih-Ya, et al.
Publicado: (2012)

Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer
por: El-Far, Ali H., et al.
Publicado: (2021)

A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats
por: Xu, Yang, et al.
Publicado: (2015)

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana
por: Liu, Qing, et al.
Publicado: (2011)

Costunolide Plays an Anti-Neuroinflammation Role in Lipopolysaccharide-Induced BV2 Microglial Activation by Targeting Cyclin-Dependent Kinase 2
por: Liu, Yan-Chen, et al.
Publicado: (2020)

Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells
por: Wei, Minyan, et al.
Publicado: (2020)

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma
por: Lin, Xuejing, et al.
Publicado: (2016)

Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower
por: Wu, Wenlong, et al.
Publicado: (2022)

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

Amelioration of Benign Prostatic Hyperplasia by Costunolide and Dehydrocostus Lactone in Wistar Rats
por: Choi, Dohyun, et al.
Publicado: (2021)

Therapeutic Effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and Experimental Validation
por: Huang, Zheng, et al.
Publicado: (2023)

Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect
por: Niu, Xia, et al.
Publicado: (2021)

Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2
por: Ban, Dujing, et al.
Publicado: (2019)

Costunolide Induces Autophagy and Apoptosis by Activating ROS/MAPK Signaling Pathways in Renal Cell Carcinoma
por: Fu, Dian, et al.
Publicado: (2020)

Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer
por: Qiu, Yinghe, et al.
Publicado: (2015)

Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells
por: Cheong, Chong-Un, et al.
Publicado: (2016)

Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated through ROS Generation and Mitochondrial Dysfunction
por: Rasul, Azhar, et al.
Publicado: (2013)

Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo
por: Huang, Hai, et al.
Publicado: (2021)

Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells
por: Liu, Chia-Yuan, et al.
Publicado: (2011)

Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson’s Disease Model
por: Arslan, Mehmet Enes, et al.
Publicado: (2023)

Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells
por: Huang, Hai, et al.
Publicado: (2021)

Costunolide, a Sesquiterpene Lactone, Suppresses Skin Cancer via Induction of Apoptosis and Blockage of Cell Proliferation
por: Lee, Sung Ho, et al.
Publicado: (2021)

Thymoquinone and Costunolide Induce Apoptosis of Both Proliferative and Doxorubicin-Induced-Senescent Colon and Breast Cancer Cells
por: El-Far, Ali H, et al.
Publicado: (2021)

Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
por: Choi, Jung‐Hye, et al.
Publicado: (2002)

Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells
por: Yan, Zhanpeng, et al.
Publicado: (2019)

LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1
por: Ji, Weidan, et al.
Publicado: (2021)

Costunolide enhances doxorubicin-induced apoptosis in prostate cancer cells via activated mitogen-activated protein kinases and generation of reactive oxygen species
por: Chen, Jiasheng, et al.
Publicado: (2017)

Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer
por: Tian, Xueli, et al.
Publicado: (2022)

Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice
por: Mao, Jingxin, et al.
Publicado: (2018)

Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress
por: Jin, Bo, et al.
Publicado: (2023)

Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer
por: Xu, Cuixiang, et al.
Publicado: (2021)

(11R)-13-Dimethylammonio-11,13-dihydro-4,5-epoxycostunolide semifumarate
por: Neelakantan, Sundar, et al.
Publicado: (2009)

Costunolide attenuates oxygen-glucose deprivation/reperfusion-induced mitochondrial-mediated apoptosis in PC12 cells
por: Meng, Lanqing, et al.
Publicado: (2021)

Costunolide Influences Germ Tube Orientation in Sunflower Broomrape – A First Step Toward Understanding Chemotropism
por: Krupp, Anna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pkri15fr5tmnbr54rd5qb1gum6