ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression. Here we report a cancer-promoting role for ATM. ATM depletion in metastatic cancer cells reduced cell migration and invasion. Transcription analyses identified a gene...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Ta, Ebelt, Nancy D, Stracker, Travis H, Xhemalce, Blerta, Van Den Berg, Carla L, Miller, Kyle M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463759/
https://www.ncbi.nlm.nih.gov/pubmed/26030852
http://dx.doi.org/10.7554/eLife.07270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463759/
https://www.ncbi.nlm.nih.gov/pubmed/26030852
http://dx.doi.org/10.7554/eLife.07270

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