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ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report

A 65-year-old woman with a limited form of systematic sclerosis (SSc) and Sjögren's syndrome (SS) was admitted to our hospital for the evaluation of renal dysfunction. Her serum creatinine was 1.6 mg/dl, proteinuria was 1.6 g/day, and the urine sediment contained 20–29 erythrocytes/high-power f...

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Autores principales: Kubota, Keiichi, Ueno, Toshiharu, Mise, Koki, Hazue, Ryo, Suwabe, Tatsuya, Kikuchi, Koichi, Hoshino, Junichi, Sumida, Keiichi, Hayami, Noriko, Takaichi, Kenmei, Fujii, Takeshi, Ohashi, Kenichi, Nonomura, Yoshinori, Ubara, Yosifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464031/
https://www.ncbi.nlm.nih.gov/pubmed/26120576
http://dx.doi.org/10.1159/000381946
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author Kubota, Keiichi
Ueno, Toshiharu
Mise, Koki
Hazue, Ryo
Suwabe, Tatsuya
Kikuchi, Koichi
Hoshino, Junichi
Sumida, Keiichi
Hayami, Noriko
Takaichi, Kenmei
Fujii, Takeshi
Ohashi, Kenichi
Nonomura, Yoshinori
Ubara, Yosifumi
author_facet Kubota, Keiichi
Ueno, Toshiharu
Mise, Koki
Hazue, Ryo
Suwabe, Tatsuya
Kikuchi, Koichi
Hoshino, Junichi
Sumida, Keiichi
Hayami, Noriko
Takaichi, Kenmei
Fujii, Takeshi
Ohashi, Kenichi
Nonomura, Yoshinori
Ubara, Yosifumi
author_sort Kubota, Keiichi
collection PubMed
description A 65-year-old woman with a limited form of systematic sclerosis (SSc) and Sjögren's syndrome (SS) was admitted to our hospital for the evaluation of renal dysfunction. Her serum creatinine was 1.6 mg/dl, proteinuria was 1.6 g/day, and the urine sediment contained 20–29 erythrocytes/high-power field. Myeloperoxidase anti-neutrophil cytoplasmic antibodies, anti-SS-A/SS-B antibodies and anti-centromere antibodies were positive. A renal biopsy showed focal necrotizing glomerulonephritis with focal interstitial lymphoplasmacytic infiltration. A diagnosis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) was made. A steroid therapy was initiated and AAV subsided. This is a rare case of AAV in a patient with anti-centromere-positive limited SSc and SS.
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spelling pubmed-44640312015-06-26 ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report Kubota, Keiichi Ueno, Toshiharu Mise, Koki Hazue, Ryo Suwabe, Tatsuya Kikuchi, Koichi Hoshino, Junichi Sumida, Keiichi Hayami, Noriko Takaichi, Kenmei Fujii, Takeshi Ohashi, Kenichi Nonomura, Yoshinori Ubara, Yosifumi Case Rep Nephrol Dial Published online: May, 2015 A 65-year-old woman with a limited form of systematic sclerosis (SSc) and Sjögren's syndrome (SS) was admitted to our hospital for the evaluation of renal dysfunction. Her serum creatinine was 1.6 mg/dl, proteinuria was 1.6 g/day, and the urine sediment contained 20–29 erythrocytes/high-power field. Myeloperoxidase anti-neutrophil cytoplasmic antibodies, anti-SS-A/SS-B antibodies and anti-centromere antibodies were positive. A renal biopsy showed focal necrotizing glomerulonephritis with focal interstitial lymphoplasmacytic infiltration. A diagnosis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) was made. A steroid therapy was initiated and AAV subsided. This is a rare case of AAV in a patient with anti-centromere-positive limited SSc and SS. S. Karger AG 2015-05-05 /pmc/articles/PMC4464031/ /pubmed/26120576 http://dx.doi.org/10.1159/000381946 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: May, 2015
Kubota, Keiichi
Ueno, Toshiharu
Mise, Koki
Hazue, Ryo
Suwabe, Tatsuya
Kikuchi, Koichi
Hoshino, Junichi
Sumida, Keiichi
Hayami, Noriko
Takaichi, Kenmei
Fujii, Takeshi
Ohashi, Kenichi
Nonomura, Yoshinori
Ubara, Yosifumi
ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title_full ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title_fullStr ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title_full_unstemmed ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title_short ANCA-Associated Vasculitis in a Patient with Systematic Sclerosis and Sjögren's Syndrome: A Case Report
title_sort anca-associated vasculitis in a patient with systematic sclerosis and sjögren's syndrome: a case report
topic Published online: May, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464031/
https://www.ncbi.nlm.nih.gov/pubmed/26120576
http://dx.doi.org/10.1159/000381946
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