Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells

Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). To identify recipient risk factors, a genome-wide study was performed including 481,820 single-nucleotide polymorphisms (SNPs). Two GVHD susceptibility loci (...

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Detalles Bibliográficos
Autores principales: Bari, Rafijul, Hartford, Christine, Keung Chan, Wing, Vong, Queenie, Li, Ying, Gan, Kwan, Zhou, Yinmei, Cheng, Cheng, Kang, Guolian, Shurtleff, Sheila, Turner, Victoria, Pui, Ching-Hon, Downing, James R., Leung, Wing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464079/
https://www.ncbi.nlm.nih.gov/pubmed/26067905
http://dx.doi.org/10.1038/srep11098

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