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Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

BACKGROUND: Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell carcinoma (RCC). Therapeutic approaches targeting CAIX have focused on the developm...

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Detalles Bibliográficos
Autores principales:	Chang, De-Kuan, Moniz, Raymond J., Xu, Zhongyao, Sun, Jiusong, Signoretti, Sabina, Zhu, Quan, Marasco, Wayne A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464115/ https://www.ncbi.nlm.nih.gov/pubmed/26062742 http://dx.doi.org/10.1186/s12943-015-0384-3

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